公开(公告)号：EP2265595A1

公开(公告)日：2010-12-29

申请号：EP09718537.5

申请日：2009-03-03

申请人： Council Of Scientific & Industrial Research

发明人： MAURYA, Rakesh ,  RAWAT, Preeti ,  SHARAN, Kunal ,  SIDDIQUI, Jawed, Akhtar ,  SWARNKAR, Gaurav ,  MISHRA, Geetanjali ,  MANICKAVASAGAM, Lakshmi ,  ARYA, Kamal, Ram ,  CHATTOPADHYAY, Naibedya ,  JAIN, Girish, Kumar .

IPC分类号： C07D309/10 ,  A61K31/352 ,  A61P19/10

CPC分类号： C07H7/06 ,  C07D405/04

摘要： The present invention provides a flavonol compound and a bioactive extract/fraction from
Ulmus wallichiana useful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R
1 =R
2 =OH K012: R
1 =R
2 =OH, 2,3 double bond K068: R
1 =R
2 =H KIOOi R
1 =OH, R
2 =H mula 2 Wherein the marker compounds K012, K058, K068, KlOO ranges 6.7 - 12%, 1.7- 4.5%, 0.6 - 1.2%, 1.7 - 4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route.

公开(公告)号：EP2265595B1

公开(公告)日：2015-07-22

申请号：EP09718537.5

申请日：2009-03-03

申请人： Council Of Scientific & Industrial Research

发明人： MAURYA, Rakesh ,  RAWAT, Preeti ,  SHARAN, Kunal ,  SIDDIQUI, Jawed, Akhtar ,  SWARNKAR, Gaurav ,  MISHRA, Geetanjali ,  MANICKAVASAGAM, Lakshmi ,  ARYA, Kamal, Ram ,  CHATTOPADHYAY, Naibedya ,  JAIN, Girish, Kumar .

IPC分类号： C07D309/10 ,  A61K31/352 ,  A61P19/10

CPC分类号： C07H7/06 ,  C07D405/04