公开(公告)号：EP1373209B1

公开(公告)日：2010-09-22

申请号：EP01934301.1

申请日：2001-03-30

申请人： Council of Scientific and Industrial Research

发明人： KULKARNI, Shivanand Janardan ,  RAGHAVAN, Kondapuram Vijaya ,  NAGABANDI, Srinivas ,  VIPPAGUNTA, Radha Rani

IPC分类号： C07D213/12

公开(公告)号：EP1472258B1

公开(公告)日：2005-11-09

申请号：EP02718502.4

申请日：2002-03-26

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： POTHURI, Sita Devi ,  KONDAPURAM, Vijaya Raghavan ,  KULKARNI, Shivanand Janardan ,  MOTKURI, Radha Kishan ,  VIPPAGUNTA, Radha Rani ,  MURTY, Mamidanna Rama Venkata Satyanarayana

IPC分类号： C07D487/22

CPC分类号： C07D487/22

摘要： The present invention provides an innovative method based on reaction cum separation on single plate concept for efficient evaluation of porphyrins, calix(4)pyrroles and allied macrocycles by in-situ synthesis from pyrrole with aromatic aldehydes and ketones over zeolite based molecular sieve catalysts as sorbents in thin layer chromatography (TLC) using microwave heating. This glass beacked zeolite coated TLC plate acts as a micro reactor as well as separator for the in-situ synthesis and chromatographic separation of macrocycles. The process is simple, economical, rapid, selective and finds a possible application in high throughput parallel synthesis and screening on a single micro plate employing microwave irradiation.