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21 条记录 (耗时 0.021 秒)

    Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof
    3.
    发明公开
    Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof 有权
    Zur Neutralisierung des Influenzavirus H5N1fähigehumaneBindungsmolekülesowie deren Verwendungen

    公开(公告)号：EP2450376A2

    公开(公告)日：2012-05-09

    申请号：EP12153009.1

    申请日：2007-09-06

    申请人： Crucell Holland B.V.

    发明人： Van Den Brink, Edward Norbert ,  De Kruif, Cornelis Adriaan ,  Throsby, Mark

    IPC分类号： C07K16/10 ,  A61K39/145 ,  C12N5/10 ,  C12N15/09

    CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C12N2760/16122

    摘要： The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo , such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.

    摘要翻译： 本发明涉及结合分子，例如与流感病毒H5N1结合并具有针对流感病毒H5N1的中和活性的人单克隆抗体。 本公开提供编码抗体的核酸分子，其序列和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H5N1感染。 在优选的实施方案中，抗体在体内提供跨亚型保护，使得可以预防和/或治疗以H5，H2，H6，H9和H1为基础的流感亚型的感染。

    Binding molecules for treatment and detection of cancer
    5.
    发明公开
    Binding molecules for treatment and detection of cancer 有权
    BINDUNGSMOLEKÜLEZUR DETEKTION VON AML

    公开(公告)号：EP2279749A1

    公开(公告)日：2011-02-02

    申请号：EP10177609.4

    申请日：2005-10-11

    申请人： Crucell Holland B.V.

    发明人： Geuijen, Cecilia A.W. ,  De Kruif, Cornelis Adriaan

    IPC分类号： A61K39/395 ,  C07K16/30

    CPC分类号： C07K16/3061 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides new tumor-associated antigens, binding molecules that specifically bind to the antigens, nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The new tumor-associated antigen are expressed on cancer cells and binding molecules capable of specifically binding to the antigens can be used in the diagnosis, prevention and/or treatment of cancer.

    摘要翻译： 本发明提供新的肿瘤相关抗原，特异性结合抗原的结合分子，编码结合分子的核酸分子，包含结合分子的组合物以及鉴定或产生结合分子的方法。 新的肿瘤相关抗原在癌细胞上表达，并且能够特异性结合抗原的结合分子可用于诊断，预防和/或治疗癌症。