-
公开(公告)号：EP3473623B1
公开(公告)日：2020-07-15
申请号：EP17819332.2
申请日：2017-06-29
发明人： CHEN, Minhua , ZHANG, Yanfeng , ZOU, Po , LIU, Kai , WANG, Jinqiu , ZHANG, Xiaoyu
IPC分类号： C07D455/08 , A61K31/473 , A61P25/14 , C07D455/06
-
公开(公告)号：EP3473623A1
公开(公告)日：2019-04-24
申请号：EP17819332.2
申请日：2017-06-29
发明人： CHEN, Minhua , ZHANG, Yanfeng , ZOU, Po , LIU, Kai , WANG, Jinqiu , ZHANG, Xiaoyu
IPC分类号： C07D455/08 , A61K31/473 , A61P25/14
摘要： The present disclosure relates to novel crystalline forms of NBI-98854 (as shown in formula I), preparation process and use thereof. The crystalline forms of NBI-98854 provided by the present disclosure, named as Form CS1 and Form CS2, can be used for preparing drug product treating tardive dyskinesia. The crystalline forms of NBI-98854 provided by the present disclosure have pharmaceutically acceptable solubility and hygroscopicity, good stability and are stable during storage, thereby avoiding changes in drug solubility, dissolution rate, bioavailability and efficacy due to polymorph transformation. This provides a new and better choice for the preparation of drug product containing NBI-98854, which has significant value for future drug development.
-
3.发明公开
公开(公告)号：EP3466958A1
公开(公告)日：2019-04-10
申请号：EP17802197.8
申请日：2017-05-25
发明人： CHEN, Minhua , ZHANG, Yanfeng , ZOU, Po , LIU, Kai , ZHANG, Xiaoyu
IPC分类号： C07H15/14 , C07H1/06 , A61K31/7028 , A61P3/10
摘要： The present disclosure relates to novel crystalline forms of a sodium-glucose co-transporter inhibitor drug (Sotagliflozin), processes for preparation and use thereof. The present disclosure also relates to pharmaceutical composition comprises novel crystalline forms of Sotagliflozin and use of novel crystalline forms and pharmaceutical composition of Sotagliflozin for preparing drugs for treating diseases. The crystalline forms provided by the present disclosure have advantages of good stability, relatively low hygroscopicity, suitability for process development and post-treatment, simple processes for preparation, low cost, and has significant value for future drug optimization and development.
-
4.发明公开
公开(公告)号：EP3701951A1
公开(公告)日：2020-09-02
申请号：EP18869512.6
申请日：2018-10-22
发明人： CHEN, Minhua , ZHANG, Yanfeng , ZHANG, Jing , ZHANG, Xiaoyu , LIU, Kai
IPC分类号： A61K31/567 , A61P5/36 , A61P15/00
摘要： The present disclosure relates to novel crystalline forms of compound I and processes for preparation thereof. The present disclosure also relates to pharmaceutical composition containing crystalline forms, and use of crystalline forms for preparing drugs containing selective progesterone receptor modulator, and use of crystalline forms for preparing drugs treating uterine fibroids and/or endometriosis. The crystalline forms of the present disclosure have one or more improved properties compared with prior art and have significant values for future drug optimization and development.
-
5.发明公开
公开(公告)号：EP3495364A1
公开(公告)日：2019-06-12
申请号：EP17836417.0
申请日：2017-08-03
发明人： CHEN, Minhua , ZHANG, Yanfeng , YANG, Cunbo , LIU, Kai , ZHANG, Xiaoyu
IPC分类号： C07D471/04 , A61K31/541 , A61P19/02 , A61P29/00
摘要： The present disclosure relates to crystalline forms of JAK1-selective inhibitor, process for preparation and use for prevention and/or treatment of diseases associated with JAK family. The crystalline forms of the present disclosure show favorable properties such as simple preparation process, good stability, low hygroscopicity and good mechanical stability.
-
公开(公告)号：EP3572399A1
公开(公告)日：2019-11-27
申请号：EP18741904.9
申请日：2018-01-09
发明人： CHEN, Minhua , ZHANG, Yanfeng , WANG, Jinqiu , LIU, Kai , ZHANG, Xiaoyu
IPC分类号： C07C323/22 , C07C59/84 , A61K31/192 , A61K31/10 , A61P1/16 , A61P3/06
摘要： The present disclosure relates to novel crystalline forms of GFT-505, processes for preparation and uses thereof. The crystalline form CS1, crystalline form CS2, crystalline form CS5 and crystalline form CS6 of GFT-505 provided by the present disclosure have high purity, good stability, low hygroscopicity, good solubility and good mechanical stability. The present disclosure provides a new and better choice for the preparation of drug products containing GFT-505 and is of great significance for drug development.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.014 秒)
