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公开(公告)号：EP4059926A1
公开(公告)日：2022-09-21
申请号：EP20886308.4
申请日：2020-11-12
发明人： CHEN, Minhua , ZHANG, Jing , ZOU, Siming
IPC分类号： C07D263/57 , A61K31/423 , A61P25/00
摘要： The present disclosure relates to novel crystalline forms of tafamidis (hereinafter referred to as compound I) and processes for preparation thereof. The present disclosure also relates to pharmaceutical composition containing the novel crystalline forms, use of the novel crystalline forms for preparing drugs treating disease caused by transthyretin-mediated amyloidosis. The crystalline forms of tafamidis of the present disclosure have one or more improved properties compared with crystalline forms of prior art and have significant value for future drug optimization and development.
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