公开(公告)号：EP1984370A1

公开(公告)日：2008-10-29

申请号：EP07701041.1

申请日：2007-01-23

申请人： Crystalgenomics, Inc. ,  YUYU Pharma, Inc.

发明人： LEE, Seung Chul ,  CHOI, Jin Seok ,  OH, Jung Hoon ,  PARK, Boonsaeng ,  KIM, Yong Eun ,  LEE, Jun Hee ,  SHIN, Dongkyu ,  KIM, Cheol Min ,  HYUN, Young-Lan ,  LEE, Cheol Soon ,  CHO, Joong-Myung ,  RO, Seonggu

IPC分类号： C07D487/04

CPC分类号： C07D471/04

摘要： The inventive imidazopyridine derivative can be used in a pharmaceutical composition for preventing or treating diseases such as diabetes, obesity, dementia, cancer, and inflammation, since it can efficiently inhibit the activities of several protein kinases including glycogen synthase kinase-3 (GSK-3), aurora kinase, extracellular signal-regulated kinase (ERK), protein kinase B (AKT), and the likes, to control signal transductions thereof.

公开(公告)号：EP2089354A1

公开(公告)日：2009-08-19

申请号：EP07833799.5

申请日：2007-11-01

申请人： Korea Research Institute Of Chemical Technology ,  Crystalgenomics, Inc.

发明人： LEE, Cheol Hae ,  JUNG, Hee Jung ,  KIM, Jae Hak ,  JEONG, Won Jang ,  CHO, Joong Myung ,  RO, Seong Gu ,  HYUN, Young Lan ,  LEE, Cheol Soon

IPC分类号： C07C233/22 ,  C07C233/16 ,  C07C217/18 ,  C07C217/16

CPC分类号： C07C259/10 ,  C07C259/06 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/27 ,  C07D207/335 ,  C07D211/10 ,  C07D211/58 ,  C07D233/64 ,  C07D295/13 ,  C07D307/14 ,  C07D307/52 ,  C07D333/20

摘要： The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.