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公开(公告)号：EP2708225A1
公开(公告)日：2014-03-19
申请号：EP13184888.9
申请日：2005-04-22
CPC分类号： A61K47/40 , A61K9/0075 , Y10T428/2982
摘要： An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physiochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delievered by DPI when SAE-CD is used as a carrier.
摘要翻译： 提供含有SAE-CD和活性剂的可吸入干粉配方。 该制剂适用于DPI的给药。 SAE-CD作为载体而不是吸收增强剂。 SAE-CD的平均粒径足够大以排除（大部分）肺沉积。 在从DPI装置释放后，含有SAE-CD的颗粒从颊腔或咽喉中含活性剂的颗粒解离，之后含活性剂的颗粒继续深入呼吸道。 SAE-CD的物理化学和形态学特性易于修饰，可以优化活性剂和载体的相互作用。 当使用SAE-CD作为载体时，具有正，中性或负静电电荷的药物可被DPI感染。
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公开(公告)号：EP2708225B1
公开(公告)日：2018-12-26
申请号：EP13184888.9
申请日：2005-04-22
CPC分类号： A61K47/40 , A61K9/0075 , Y10T428/2982
摘要： An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physiochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delievered by DPI when SAE-CD is used as a carrier.
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