公开(公告)号：EP1755551A2

公开(公告)日：2007-02-28

申请号：EP05743067.0

申请日：2005-04-22

申请人： Cydex Inc.

发明人： PIPKIN, James, D. ,  ZIMMERER, Rupert, O. ,  HICKEY, Anthony, J. ,  THOMPSON, Diane, O. ,  SMYTH, Hugh, D., C.

IPC分类号： A61K9/00

CPC分类号： A61K47/40 ,  A61K9/0075 ,  Y10T428/2982

摘要： An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.