公开(公告)号：EP0500835B1

公开(公告)日：1996-12-27

申请号：EP91914696.9

申请日：1991-08-14

申请人： DAEWOONG PHARMACEUTICAL CO., LTD.

发明人： YOON, Geal, Jung, 102-103 Sungji APT. ,  KIM, Dae, Young, Na-202 Taeyangyunlip ,  LEE, Jae, Wook, 107-410 Sungji APT. ,  PARK, Nam, Jun, 103-1402 Jukong APT. ,  LEE, Kyeu, Sam, 51-2, Singongdug-Dong ,  KANG, Tae, Choong, 108-402 Sungji APT.

IPC分类号： C07D401/04 ,  C07D203/06 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  A61K31/445

CPC分类号： C07D207/08 ,  C07D205/04 ,  C07D211/54 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to a novel quinolone carboxylic acid derivative of structural formula (I) and pharmaceutically acceptable salts thereof. These compounds also have a potent activity against both Gram-positive bacteria and Gram-negative bacteria; wherein R1 is hydrogen or alkyl group having one to six carbon atoms, R2 is alkyl group having one to four carbon atoms, haloalkyl group having one to four carbon atoms, cycloalkyl group having three to six carbon atoms, alkenyl group having two to four carbon atoms, or phenyl group which is optionally mono or disubstituted by fluorine atoms, X is hydrogen, amino, or halogen, Y is hydrogen or halogen, Z is (II) (wherein l is 1 or 2, m is 0, 1, or 2, and n is 0 or 1, R3 is hydrogen, alkyl group having one to four carbon atoms, haloalkyl group having one to three carbon atoms, acyl group, cycloalkyl group having three to six carbon atoms, aryl, or heteroaryl group).