公开(公告)号：EP0953359A1

公开(公告)日：1999-11-03

申请号：EP97949114.9

申请日：1997-12-17

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： TAKAHASHI, Masayuki, Daiichi Pharmaceut. Co., Ltd. ,  MORITA, Hiromi, Daiichi Pharmaceutical Co., Ltd. ,  KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd.

IPC分类号： A61K47/40

CPC分类号： A61K9/4858 ,  A61K47/14 ,  A61K47/40

摘要： The present invention is directed to a pharmaceutical composition for oral administration, comprising a basic drug, a lipophilic substance, and/or a cyclodextrin.
The composition exhibits improved peroral absorption of a basic drug which is difficult to be absorbed by oral administration.

公开(公告)号：EP0896816A1

公开(公告)日：1999-02-17

申请号：EP97905406.1

申请日：1997-02-26

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： YAMAUCHI, Hitoshi, Daiichi Pharmaceutical Co., Ltd ,  MORITA, Hiromi, Daiichi Pharmaceutical Co., Ltd. ,  KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd.

IPC分类号： A61K9/127 ,  A61K47/24 ,  A61K31/557

CPC分类号： A61K9/1272 ,  A61K9/1271

摘要： This invention aims at improving stability of drugs which have poor stability in aqueous solution, and the stability of such drugs are improved by incorporating the drugs in liposomes which have a sphingolipid as the main component of the liposomal membrane-constituting lipids.

摘要翻译： 本发明旨在提高在水溶液中稳定性差的药物的稳定性，并且通过将药物掺入脂质体作为脂质体构成脂质的主要成分的脂质体来提高这些药物的稳定性。