公开(公告)号：EP1745801A1

公开(公告)日：2007-01-24

申请号：EP05737308.6

申请日：2005-04-28

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： WADA, Naoya, Daiichi Pharmaceutical Co., Ltd. ,  OKAMOTO, Takashi, Daiichi Pharmaceutical Co., Ltd. ,  TANIGAKI, Keiji ,  DOI, Hirofumi, Celestar Lexico-Sciences, Inc. ,  KITUCHI, Y., Celestar Lexico-Sciences, Inc. ,  IMAI, K., Celestar Lexico-Sciences, Inc.

IPC分类号： A61K45/00 ,  A61K38/55 ,  A61P35/00 ,  A61P43/00 ,  C12Q1/48 ,  G01N33/15 ,  G01N33/50 ,  C12N9/99 ,  C12N15/09

CPC分类号： C12N9/1205

摘要： The present invention provides a method for inhibiting the activation of telomerase and an agent for inhibiting the activation of telomerase, a method for inhibiting telomerase activity and an agent for inhibiting telomerase activity, a method for preventing and/or a method for treating a cancer disease, an agent for preventing and/or an agent for treating a cancer disease, all of which comprises inhibiting the binding of MAPKAPK3 to TERT that is a catalytic subunit of telomerase or inhibiting the phosphorylation of TERT by active MAPKAPK3; a method of identifying a compound that inhibits the binding of MAPKAPK3 to TERT or a compound that inhibits the phosphorylation of TERT by active MAPKAPK3; and a reagent kit.

摘要翻译： 本发明提供一种抑制端粒酶活化的方法和抑制端粒酶活化的试剂，抑制端粒酶活性的方法和抑制端粒酶活性的方法，预防和/或治疗癌症的方法 ，用于预防和/或治疗癌症疾病的药物，所有这些都包括抑制MAPKAPK3与作为端粒酶催化亚单位的TERT的结合或抑制活性MAPKAPK3的TERT磷酸化; 一种鉴定抑制MAPKAPK3与TERT结合的化合物或抑制活性MAPKAPK3磷酸化TERT的化合物的方法; 和试剂盒。