公开(公告)号：EP1389463A1

公开(公告)日：2004-02-18

申请号：EP02722752.9

申请日：2002-04-24

申请人： DAIICHI PHARMACEUTICAL CO., LTD. ,  Essential Therapeutics, Inc.

发明人： NAKAYAMA, K., c/o Daiichi Pharmaceutical Co., Ltd ,  OHTSUKA, M., c/o Daiichi Pharmaceutical Co., Ltd. ,  KAWATO, H., c/o Daiichi Pharmaceutical Co., Ltd ,  OKUMURA, R., c/o Daiichi Pharmaceutical Co., Ltd. ,  HOSHINO, K., c/o Daiichi Pharmaceutical Co., Ltd. ,  WATKINS, W., c/o Essential Therapeutics, Inc. ,  ZHANG, Jason, c/o Essential Therapeutics, Inc. ,  PALME, Monica, c/o Essential Therapeutics, Inc. ,  CHO, Aesop, c/o Essential Therapeutics, Inc.

IPC分类号： A61K31/549 ,  A61K45/00 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/4709 ,  A61P31/04 ,  A61P31/00 ,  A61P43/00 ,  C12Q1/18 ,  C12Q1/02 ,  G01N33/15

CPC分类号： C07D417/06 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D417/12 ,  C07D471/04 ,  C12Q1/18

摘要： A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I):
wherein, R 1 and R 2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W 1 represents -CH=CH-, -CH 2 O-, -CH 2 CH 2 - or the like; R 3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R 4 represents hydrogen atom, a group of -OZ 0-4 R 5 (Z 0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R 5 represents a cyclic alkyl group, an aryl group or the like); W 2 represents a single bond or -C(R 8 )=C(R 9 )- (R 8 and R 9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W 2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.

摘要翻译： 一种用于预防和/或治疗微生物感染的药物，其包含作为活性成分的由以下通式（I）表示的化合物：其中R 1和R 2表示氢原子， 卤素原子，羟基等，W 1表示-CH = CH-，-CH 2 O - ， - CH 2 CH 2 - 等; R 3表示氢原子，卤素原子，羟基或氨基; R 4表示氢原子，-OZO 4 R 5基团（Z 0-4表示亚烷基，氟取代的亚烷基或单键，R 5表示环状烷基， 芳基等）; W 2表示单键或-C（R 8）= C（R 9） - （R 8和R 9）表示氢原子，卤素原子，低级烷基或 Q表示酸性基团，但W 2和Q可以一起形成亚乙基二氮烷二酮或等价杂环; m和n表示0〜2的整数，q表示0〜3的整数。