公开(公告)号：EP0947513A4

公开(公告)日：2002-10-02

申请号：EP97909605

申请日：1997-10-23

申请人： DAIICHI SEIYAKU CO

发明人： TAKEMURA MAKOTO ,  TAKAHASHI HISASHI ,  KIMURA KENICHI ,  MIYAUCHI RIE ,  OHKI HITOSHI ,  KAWAKAMI KATSUHIRO

IPC分类号： C07D401/04 ,  C07D455/02 ,  C07D471/04 ,  C07D491/16 ,  C07D498/04 ,  C07D498/06 ,  C07D513/04 ,  A61K31/47 ,  C07D209/94 ,  C07D455/06

CPC分类号： C07D401/04 ,  C07D455/02 ,  C07D471/04 ,  C07D513/04

摘要： Compounds represented by general formula (I) carrying a tricylic amine substituent optionally having various substituents, their salts, hydrates thereof or drugs containing these compounds as the active ingredient. Because of having favorable antibacterial activities on gram-negative and gram-positive bacteria and being excellent both in the dynamics in vivo and safety, these compounds are useful in treating infectious diseases. In said formula (I), Q represents a partial structure which is preferably represented by formula (a); or (b) and may have various substituents.

摘要翻译： 由通式（I）表示的带有任选具有各种取代基的三取代胺取代基的化合物，其盐，其水合物或含有这些化合物的药物作为活性成分。 由于对革兰氏阴性菌和革兰氏阳性菌具有良好的抗菌活性，并且在体内动力学和安全性方面均优异，所以这些化合物可用于治疗感染性疾病。 在所述式（I）中，Q表示优选由式（a）表示的部分结构; 或（b）并可具有各种取代基。

公开(公告)号：EP0807630A4

公开(公告)日：1998-05-13

申请号：EP96901518

申请日：1996-02-01

申请人： DAIICHI SEIYAKU CO

发明人： TAKEMURA MAKOTO ,  KIMURA YOUICHI ,  KAWAKAMI KATSUHIRO ,  KIMURA KENICHI ,  OHKI HITOSHI ,  MATSUHASHI NORIKAZU ,  KAWATO HARUKO

IPC分类号： C07D401/04 ,  A61K31/435 ,  A61K31/47 ,  C07D471/04

CPC分类号： C07D401/04

摘要： N1-(Halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by general formula (I), heterocyclic compounds useful as antibacterial agents, wherein X1 represents halo or hydrogen; X2 represents halo; R1 represents hydrogen, hydroxy, thiol, halomethyl, amino, alkyl or alkoxy; R2 represents a group of general formula (II) (wherein R?3 and R4¿ represent each hydrogen or alkyl; and n represents an integer of 1 or 2); A represents nitrogen or a group of general formula (III), (wherein X3 represents halo, cyano, amino, alkyl, halomethyl, alkoxy or halomethoxy); and R represents hydrogen, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1, 3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl or phenylalkyl.

公开(公告)号：EP0995744A4

公开(公告)日：2001-02-07

申请号：EP98928627

申请日：1998-06-23

申请人： DAIICHI SEIYAKU CO

发明人： TAKEMURA MAKOTO ,  TAKAHASHI HISASHI ,  OHKI HITOSHI ,  KIMURA KENICHI ,  MIYAUCHI RIE ,  TAKEDA TOSHIYUKI

IPC分类号： C07D401/04 ,  A61K31/47 ,  C07D207/14

CPC分类号： C07D401/04

摘要： Quinolone derivatives represented by general formula (I), salts thereof, and hydrates thereof of both, having potent antimicrobial activities against various bacteria including resistant strains and being highly safe: wherein R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R2 represents a halogenomethoxyl or alkoxyl group; R3 represents an alkyl, alkenyl, halogenoalkyl, cyclic alkyl, heteroaryl, alkoxyl, or alkylamino group; R4 represents a hydrogen atom or a phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl, or phenylalkyl group. The above substituents may be further substituted.