公开(公告)号：EP0916348A4

公开(公告)日：2000-11-29

申请号：EP97924325

申请日：1997-06-05

申请人： DAIICHI SEIYAKU CO ,  DRUG DELIVERY SYSTEM INST LTD

发明人： INOUE KAZUHIRO ,  SUSAKI HIROSHI ,  IKEDA MASAHIRO ,  KUGA HIROSHI ,  KUMAZAWA EIJI ,  TOGO AKIKO

IPC分类号： A61K47/48

CPC分类号： A61K47/61

摘要： Drug complexes wherein a carboxy (C1-4)alkyldextran polyalcohol, which has been treated under such conditions as to allow the substantially complete formation of the polyalcohol, is bonded to the residue of a medicinal compound such as an antitumor agent via a spacer consisting of one amino acid or a spacer consisting of two to eight amino acids bonded to each other via peptide bonds. The complexes are excellent in the tumor site selectivity and thus can exhibit a high antitumor effect with relieved expression of toxicity.