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    Process for producing 4-amino-methylbicyclo(2,2,2)octane-1-carboxylic acid and intermediate compound therefor
    1.
    发明公开
    Process for producing 4-amino-methylbicyclo(2,2,2)octane-1-carboxylic acid and intermediate compound therefor 失效
    一种用于4-氨基甲基双环（2,2,2）辛烷-1-羧酸及其中间体的制备方法。

    公开(公告)号：EP0003409A1

    公开(公告)日：1979-08-08

    申请号：EP79300082.9

    申请日：1979-01-17

    申请人： DAIICHI SEIYAKU CO., LTD.

    发明人： Shimada, Sadakatsu ,  Yukimoto, Yusuke

    IPC分类号： C07C99/00 ,  C07C101/04

    CPC分类号： C07C255/45

    摘要： Process for producing 4-aminomethylbicyclo (2,2,2)octane-1-carboxylic acid and intermediate therefor 4-aminomethylbicyclo(2,2,2)octane-1-carboxylic acid or a pharmaceutically acceptable salt thereof is prepared by reacting a compound of the formula:
    (wherein R is a hydrogen atom or a lower alkyl group) with ethylene, under a pressure of 60 to 300 kg/cm 2 at a temperature of 100°-250°C. to produce a 4-cyanobicyclo(2,2,2,)oct-2-en-1-carboxylic acid of the formula:
    (wherein R is the same as defined above), catalytically reducing the bicyclo compound and hydrolyzing the reduction product.

    摘要翻译： 用于生产4-氨基甲基（2,2,2）辛烷-1-羧酸和中间为此4-氨基甲基（2,2,2）辛烷-1-羧酸或者其药学上可接受的盐是通过使化合物制备 下式：（worin R是氢原子或低级烷基）与乙烯，60至300公斤/厘米<2>的压力下在100℃-250℃的温度下，以产生 式的4- cyanobicyclo（2,2,2）辛-2-烯-1-甲酸的制备：（worin R为如上所定义的相同），催化还原的双环化合物和水解该还原产物。