公开(公告)号：EP1051383B1

公开(公告)日：2004-07-28

申请号：EP99901732.0

申请日：1999-02-02

申请人： DE MONTFORT UNIVERSITY

发明人： POTTER, Gerard Andrew ,  PATTERSON, Lawrence Hylton ,  BURKE, Michael Danny ,  BUTLER, Paul Crispin

IPC分类号： C07C49/84 ,  C07C43/215 ,  C07C205/35 ,  C07C255/36 ,  C07D213/57 ,  A61K31/09 ,  A61K31/12

CPC分类号： C07C43/215 ,  C07C49/84 ,  C07C205/35 ,  C07C255/36 ,  C07C327/48 ,  C07C2602/10 ,  C07D213/57

摘要： The present invention concerns enzymatic aromatic hydroxylation-activated prodrugs, particularly anti-tumour prodrugs and those which are specifically activated by the hydroxylation activity of the enzyme CYP1B1.