公开(公告)号：EP1857818A1

公开(公告)日：2007-11-21

申请号：EP06009954.6

申请日：2006-05-15

申请人： DIGILAB BioVisioN GmbH

发明人： Budde, Petra, Dr. ,  Zucht, Hans-Dieter, Dr. ,  Tammen, Harald, Dr. ,  Hess, Rüdiger, Dr. ,  Menzel, Christoph, Dr

IPC分类号： G01N33/68 ,  C07K14/765 ,  C07K14/575 ,  A61P3/10

CPC分类号： C07K14/765 ,  G01N33/6893 ,  G01N2800/042

摘要： The present invention is in the field of diagnostics and therapeutics. Specifically, the present invention provides methods for diagnosis and therapy of diseases and conditions associated with oxidative stress such as Type 2 diabetes, hyperglycaemia, preeclampsia, aging, etc. Furthermore the invention provides peptides, binding agents recognizing said peptides, diagnostic assay kits, and compositions suitable for medical purposes. The peptides of the invention are characterized by a C-terminal, non-enzymatic originated amide or by a nitric oxide binding site. The peptides of the invention are suitable as biomarker or as therapeutic substances capable to function as nitric oxide delivery vehicles.

摘要翻译： 本发明是在诊断和治疗的领域。 具体而言，本发明提供了用于治疗与氧化应激相关的疾病和病症的诊断和治疗的方法：例如2型糖尿病，高血糖症，先兆子痫，老化等进一步，本发明提供的肽，结合剂识别所述肽，诊断测定试剂盒和 适合用于医疗目的的组合物。 本发明的肽通过C末端为特征的，非酶源自酰胺或由一氧化氮结合位点。 本发明的肽是适合作为生物标志物或能够用作一氧化氮输送车作为治疗物质。