公开(公告)号：EP1344829A4

公开(公告)日：2005-01-05

申请号：EP01997561

申请日：2001-11-27

申请人： DNAVEC RESEARCH INC

发明人： YONEMITSU YOSHIKAZU ,  SUEISHI KATSUO ,  FUKUMURA MASAYUKI ,  HOU XIAOGANG ,  HASEGAWA MAMORU

IPC分类号： A61K48/00 ,  C07K14/50 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/50 ,  C12N2760/18843 ,  C12N2800/30

摘要： A paramyxovirus vector encoding an angiogenesis gene. Use of the paramyxovirus vector makes it possible to efficiently transfer the angiogenesis gene into an individual tissue. FGF2 gene administered in vivo expresses the angiogenesis gene accompanied by no edema in an ischemic tissue, thereby preventing necrosis due to the ischemia. This vector is appropriately usable in gene therapy targeting ischemic tissues.