公开(公告)号：EP3262422B1

公开(公告)日：2020-03-18

申请号：EP16706602.6

申请日：2016-02-25

申请人： DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH ,  Johann Wolfgang Goethe-Universität Frankfurt am Main

发明人： BÖNIG, Halvard ,  GEISEN, Christof ,  WIERCINSKA, Eliza Justyna ,  RYSCHKA, Nikolas

IPC分类号： G01N33/53 ,  G01N33/80 ,  C07K16/34 ,  B01D15/38 ,  G01N33/50

公开(公告)号：EP3262422A2

公开(公告)日：2018-01-03

申请号：EP16706602.6

申请日：2016-02-25

申请人： DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH ,  Johann Wolfgang Goethe-Universität Frankfurt am Main

发明人： BÖNIG, Halvard ,  GEISEN, Christof ,  WIERCINSKA, Eliza Justyna ,  RYSCHKA, Nikolas

IPC分类号： G01N33/80 ,  C07K16/34 ,  B01D15/38 ,  G01N33/50

摘要： The present invention provides a cellular system for the detection of the presence of one or more antibody species in sample, preferably a serum or plasma sample. The method is in particular useful for the analysis of patients who have been sensitized against blood group antigens expressed on erythrocytes, platelets or granulocytes. The system uses fluorescence labeled cells specific for each antigen and hence, for each antibody species. Provided are the methods, system and diagnostic kits for performing the methods of the invention. In addition, the present invention discloses a method for removing antibodies from a sample such as a serum sample. Such a method is useful for absorbing antibodies from poly-agglutinating sera.