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公开(公告)号：EP0544000B1
公开(公告)日：1997-05-02
申请号：EP91914632.4
申请日：1991-08-16
发明人： INOUE, Kazuhiro, 5-6-6, Matsugaoka , ITO, Teruomi, 6-89-104, Shinmatsudo , OKUNO, Satoshi, 8-5-18, Waseda , AONO, Katsutoshi,
CPC分类号： C08B37/003
摘要： A novel N-acetylcarboxymethylchitosan derivative represented by general formula (I) and having the following properties (1) to (4): (1) degree of carboxymethylation: 0.5 - 1.2, (2) molecular weight (according to gel filtration): 3,000 - 300,000, (3) a/(a+b): 0.01 - 1 wherein a = a1 + a2, (4) P/X (by mole): 0.1 - 1. Formula (I), wherein R1 and R2 represent each hydrogen or carboxymethyl; P represents R3CO, R4NH or R5O; Q represents hydrogen or hydroxy; X represents a peptide chain containing 1 to 10 same or different amino acid residues; R3COOH, R4NH2 and R5OH represent carboxylic acid, amine and alcohol compounds, respectively; a1 and a2 represent each 0 or a positive integer except for the case where both of them are 0 at the same time; and b represents a positive integer. When the P group in the formula (I) represents a group derived from a pharmaceutical compound, the substance of the formula (I) is useful as a drug improved in the directivity toward a target organ.
摘要翻译： （1）〜（4）所示的新型N-乙酰羧甲基壳聚糖衍生物：（1）羧甲基化度：0.5〜1.2，（2）分子量（根据凝胶过滤）：3,000 式（I）中，R 1和R 2分别表示 - （ - ） - 300,000，（3）a /（a + b）：0.01-1其中a = a1 + a2，（4）P / 氢或羧甲基; P表示R3CO，R4NH或R5O; Q代表氢或羟基; X代表含有1至10个相同或不同氨基酸残基的肽链; R 3 COOH，R 4 NH 2和R 5 OH分别代表羧酸，胺和醇化合物; 除了两者同时为0的情况之外，a1和a2分别表示0或正整数; b表示正整数。 当式（I）中的P基团表示来源于药物化合物的基团时，式（I）的物质可用作改善靶器官指向性的药物。
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公开(公告)号：EP0544000A1
公开(公告)日：1993-06-02
申请号：EP91914632.4
申请日：1991-08-16
发明人： INOUE, Kazuhiro, 5-6-6, Matsugaoka , ITO, Teruomi, 6-89-104, Shinmatsudo , OKUNO, Satoshi, 8-5-18, Waseda , AONO, Katsutoshi,
CPC分类号： C08B37/003
摘要： A novel N-acetylcarboxymethylchitosan derivative represented by general formula (I) and having the following properties (1) to (4): (1) degree of carboxymethylation: 0.5 - 1.2, (2) molecular weight (according to gel filtration): 3,000 - 300,000, (3) a/(a+b) : 0.01 - 1 wherein a = a₁ + a₂ , (4) P/X (by mole): 0.1 - 1. Formula (I), wherein R₁ and R₂ represent each hydrogen or carboxymethyl; P represents R₃CO, R₄NH or R₅O; Q represents hydrogen or hydroxy; X represents a peptide chain containing 1 to 10 same or different amino acid residues; R₃COOH, R₄NH₂ and R₅OH represent carboxylic acid, amine and alcohol compounds, respectively; a₁ and a₂ represent each 0 or a positive integer except for the case where both of them are 0 at the same time; and b represents a positive integer. When the P group in the formula (I) represents a group derived from a pharmaceutical compound, the substance of the formula (I) is useful as a drug improved in the directivity toward a target organ.
摘要翻译： （1）〜（4）所示的新型N-乙酰羧甲基壳聚糖衍生物：（1）羧甲基化度：0.5〜1.2，（2）分子量（根据凝胶过滤）：3,000 式（I）中，R 1和R 2分别代表各自独立的碳原子数为1〜3的（a），（b）， 氢或羧甲基; P代表R 3 CO，R 4 NH或R 5 O; Q代表氢或羟基; X代表含有1至10个相同或不同氨基酸残基的肽链; R 3 COOH，R 4 NH 2和R 5 OH分别代表羧酸，胺和醇化合物; a 1和a 2分别代表0或正整数，除了它们两者同时为0的情况; b表示正整数。 当式（I）中的P基团表示来源于药物化合物的基团时，式（I）的物质可用作改善靶器官指向性的药物。
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