公开(公告)号：EP2664340A3

公开(公告)日：2013-12-11

申请号：EP13176325.2

申请日：2006-06-21

申请人： DUKE UNIVERSITY

发明人： Setton, Lori A. ,  Chilkoti, Ashutosh ,  Kraus, Virginia B. ,  Betre, Helawe ,  Dreher, Matthew R.

IPC分类号： A61K38/20 ,  A61K38/39 ,  A61K39/44 ,  A61K47/42 ,  A61K47/48 ,  A61M31/00 ,  A61P19/02 ,  A61P29/00

CPC分类号： C07K14/78 ,  A61K9/0024 ,  A61K47/42 ,  A61K47/642 ,  A61K47/6435 ,  C07K14/7155

摘要： A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.

公开(公告)号：EP2664340B1

公开(公告)日：2020-02-12

申请号：EP13176325.2

申请日：2006-06-21

申请人： DUKE UNIVERSITY

发明人： Setton, Lori A. ,  Chilkoti, Ashutosh ,  Kraus, Virginia B. ,  Betre, Helawe ,  Dreher, Matthew R.

IPC分类号： A61K9/00 ,  A61K47/42 ,  A61P19/02 ,  A61P29/00 ,  A61K38/20 ,  A61K39/44

公开(公告)号：EP2664340A2

公开(公告)日：2013-11-20

申请号：EP13176325.2

申请日：2006-06-21

申请人： DUKE UNIVERSITY

发明人： Setton, Lori A. ,  Chilkoti, Ashutosh ,  Kraus, Virginia B. ,  Betre, Helawe ,  Dreher, Matthew R.

IPC分类号： A61K38/20 ,  A61K38/39 ,  A61K39/395 ,  A61K39/44 ,  A61K47/42 ,  A61K47/48 ,  A61M31/00 ,  A61P19/02 ,  A61P29/00

CPC分类号： C07K14/78 ,  A61K9/0024 ,  A61K47/42 ,  A61K47/642 ,  A61K47/6435 ,  C07K14/7155

摘要： A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.

摘要翻译： 将感兴趣的化合物的药物贮库递送到受试者的选定区域的方法。 所述方法包括将组合物直接施用于所述感兴趣区域，所述组合物包含待递送的目标化合物（例如抗炎剂或化学治疗剂）和经历的化合物（例如弹性蛋白样肽或ELP） 逆温度相变，从而提供在所选区域的感兴趣的化合物的持续释放。 还描述了用于实施本发明的组合物。