公开(公告)号：EP0742203B1

公开(公告)日：1999-09-29

申请号：EP96201133.4

申请日：1996-05-07

申请人： DUPHAR INTERNATIONAL RESEARCH B.V

发明人： Kutner, Andrzej, Octrooibureau Zoan B.V ,  Wojciechowska, Wanda, c/o Octrooibuerau Zoan B.V ,  Halkes, Sebastianus J.,c/o Octrooibureau Zoan B.V ,  Van de Velde, Jan-Paul, c/o Octrooibureau Zoan B.V

IPC分类号： C07C401/00 ,  A61K31/59

CPC分类号： C07F7/1856 ,  C07C401/00 ,  C07J51/00

公开(公告)号：EP0742203A3

公开(公告)日：1996-12-04

申请号：EP96201133.4

申请日：1996-05-07

申请人： DUPHAR INTERNATIONAL RESEARCH B.V

发明人： Kutner, Andrzej, Octrooibureau Zoan B.V ,  Wojciechowska, Wanda, c/o Octrooibuerau Zoan B.V ,  Halkes, Sebastianus J.,c/o Octrooibureau Zoan B.V ,  Van de Velde, Jan-Paul, c/o Octrooibureau Zoan B.V

IPC分类号： C07C401/00 ,  A61K31/59

CPC分类号： C07F7/1856 ,  C07C401/00 ,  C07J51/00

摘要： The invention relates to a vitamin D compound of the general formula

wherein
   R 1 is a hydrogen atom or a hydroxy group,
   R 2 is a hydrogen atom or a substituent selected from the group consisting of (C 1 -C 3 )alkyl, phenyl and trifluoromethyl,
   R 3 is a branched or unbranched (C 1 -C 4 )alkyl group or a cyclopropyl group or a CF, group,
   A and B are each individually hydrogen atoms or methyl groups, or A and B form together a methylene group,
   X is CH 2 or O,
    n is 2 or 3. The invention further relates to methods of preparing these compounds, to methods for preparing a valuable intermediate in the preparation of these compounds and to their use in pharmacotherapy and cosmetics.

摘要翻译： 本发明涉及如下通式的维生素D化合物其中R 1是氢原子或羟基，R 2是氢原子或选自（C 1 -C 3）烷基，苯基和三氟甲基的取代基，R 3是 支链或无支链（C1-C4）烷基或环丙基或CF，基团A和B各自独立地为氢原子或甲基，或者A和B一起形成亚甲基，X为CH2或O，n 本发明进一步涉及制备这些化合物的方法，制备这些化合物中有价值的中间体的方法以及它们在药物疗法和化妆品中的用途。

公开(公告)号：EP0742203A2

公开(公告)日：1996-11-13

申请号：EP96201133.4

申请日：1996-05-07

申请人： DUPHAR INTERNATIONAL RESEARCH B.V

发明人： Kutner, Andrzej, Octrooibureau Zoan B.V ,  Wojciechowska, Wanda, c/o Octrooibuerau Zoan B.V ,  Halkes, Sebastianus J.,c/o Octrooibureau Zoan B.V ,  Van de Velde, Jan-Paul, c/o Octrooibureau Zoan B.V

IPC分类号： C07C401/00 ,  A61K31/59

CPC分类号： C07F7/1856 ,  C07C401/00 ,  C07J51/00

摘要： The invention relates to a vitamin D compound of the general formula

wherein
   R 1 is a hydrogen atom or a hydroxy group,
   R 2 is a hydrogen atom or a substituent selected from the group consisting of (C 1 -C 3 )alkyl, phenyl and trifluoromethyl,
   R 3 is a branched or unbranched (C 1 -C 4 )alkyl group or a cyclopropyl group or a CF, group,
   A and B are each individually hydrogen atoms or methyl groups, or A and B form together a methylene group,
   X is CH 2 or O,
    n is 2 or 3.
The invention further relates to methods of preparing these compounds, to methods for preparing a valuable intermediate in the preparation of these compounds and to their use in pharmacotherapy and cosmetics.

摘要翻译： 本发明涉及通式的维生素D化合物，其中R1是氢原子或羟基，R2是氢原子或选自（C1-C3）烷基，苯基和三氟甲基的取代基 ，R 3为支链或非支链（C1-C4）烷基或环丙基或CF，基团A和B各自为氢原子或甲基，或A和B一起形成亚甲基，X为CH 2或 O，n为2或3.本发明还涉及制备这些化合物的方法，制备这些化合物的制备中的有价值的中间体的方法及其在药物治疗和化妆品中的应用。