公开(公告)号：EP4253417A1

公开(公告)日：2023-10-04

申请号：EP21898429.2

申请日：2021-11-09

申请人： Daegu Gyeongbuk Institute Of Science and Technology ,  Kosin University Industry-Academy Cooperation ,  Inje University Industry-Academic Cooperation Foundation

发明人： YEA, Kyung Moo ,  JEONG, Jee-Yeong ,  PARK, Sea Gwang ,  SHIN, Ji Won ,  KIM, Min-Jung

IPC分类号： C07K16/28 ,  A61P7/06 ,  A61K39/00

摘要： The present invention relates to a novel anti-C-MPL antibody and a use thereof, and specifically, to an anti-C-MPL antibody having an effect of increasing platelet production and its number through the maturation of megakaryocytes in the bone marrow, and a use thereof. The novel anti-C-MPL antibody (2R13) of the present invention is a polymer material and has a longer half-life than the conventional therapeutic agents, and it has the advantage of low self-antibody production and low immunogenicity as an antibody agent. In addition, it can be used as a therapeutic agent for thrombocytopenia by increasing the platelet level of patients suffering from chronic or complication-induced immune thrombocytopenia.