公开(公告)号：EP3604304A1

公开(公告)日：2020-02-05

申请号：EP18770572.8

申请日：2018-03-23

申请人： Daegu-Gyeongbuk Medical Innovation Foundation ,  Korea Research Institute of Bioscience and Biotechnology ,  Daegu Gyeongbuk Institute of Science and Technology

发明人： CHOI, Hwan Geun ,  KO, Eunhwa ,  CHO, Joong-heui ,  SON, Jung Beom ,  KO, Yi Kyung ,  PARK, Jin-Hee ,  KIM, So Young ,  KANG, Seock Yong ,  LEE, Seungyeon ,  RYU, Hee Yoon ,  KIM, Nam Doo ,  KIM, Sang Bum ,  LEE, Sun-Hwa ,  KIM, Dayea ,  LEE, Sun Joo ,  CHO, Sungchan ,  LEE, Kyu-Sun ,  YU, Kweon ,  CHOI, Miri ,  KOO, Ja Wook ,  HOE, Hyang-Sook

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/5377 ,  A23L33/10

摘要： The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

公开(公告)号：EP3587422A2

公开(公告)日：2020-01-01

申请号：EP18757481.9

申请日：2018-02-22

申请人： Daegu-Gyeongbuk Medical Innovation Foundation ,  National Cancer Center ,  Samsung Life Public Welfare Foundation

发明人： CHOI, Hwan Geun ,  PARK, Jong Bae ,  KO, Eunhwa ,  SON, Jung Beom ,  CHO, Joong-heui ,  KO, Yi Kyung ,  PARK, Jin-Hee ,  KIM, So Young ,  KANG, Seock Yong ,  LEE, Seungyeon ,  KIM, Nam Doo ,  LEE, Yunho ,  LEE, Sun-Hwa ,  KIM, Dayea ,  LEE, Sun Joo ,  BAE, Jae Hyun ,  HONG, Eunmi ,  JANG, Tae-ho ,  KIM, Sang Bum ,  LEE, Seung Hoon ,  NAM, Do-Hyun

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A23L33/10

摘要： The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.