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公开(公告)号：EP1142586B1
公开(公告)日：2007-04-25
申请号：EP00971729.9
申请日：2000-11-01
发明人： FUKAMI, Harukazu , URATA, Hidenori
IPC分类号： A61K31/517 , A61P9/10
CPC分类号： A61K31/517 , C07D239/96
摘要： Preventive or therapeutic agents for diseases accompanied with vascular function disorders related to deposition of lipid on vessel walls, containing specific chymase inhibitors as the active ingredient. Quinazoline derivatives of general formula (1) are usable as the specific chymase inhibitor. In said formula, A is an aromatic ring.
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公开(公告)号：EP1114035B1
公开(公告)日：2006-05-17
申请号：EP99938565.1
申请日：1999-08-20
发明人： FUKAMI, Harukazu , ITO, Akiko , IMAJO, Seiichi
IPC分类号： C07D239/96 , C07D403/12 , C07D413/12 , A61K31/505 , A61P9/10 , A61P11/06 , A61P37/08
CPC分类号： C07D401/12 , C07C311/60 , C07D239/96 , C07D413/12
摘要： A quinazoline derivative having formula (I), or a pharmaceutically acceptable salt thereof, which has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase and useful as a medicament, and a pharmaceutical composition containing the same as an essential ingredient.
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3.发明授权THERAPEUTIC TREATMENT OF EOSINOPHILIA USING CHYMASE INHIBITORS AS THE ACTIVE INGREDIENT 有权按用途分的抑制剂作为活性成分糜酶嗜酸细胞治疗
公开(公告)号：EP1174151B1
公开(公告)日：2007-01-24
申请号：EP01906225.6
申请日：2001-02-22
IPC分类号： A61K45/00 , A61K31/517 , A61K31/536 , A61P43/00 , A61P37/08 , A61P11/06 , A61P27/16 , A61P27/14 , A61P17/04 , C07D239/96
CPC分类号： C07D239/96 , A61K31/00 , A61K31/517 , A61K31/536
摘要： Preventive or therapeutic drugs, which inhibit the progression of eosinophilia-related diseases while preventing the progression of various complications, and are so safe by virtue of their being free from adverse effects as to bring about enhancement in the quality of daily life of a patient. Specifically, preventive or therapeutic drugs for eosinophilia-related diseases containing chymase inhibitors as the active ingredient, wherein the chymase inhibitors are quinazoline derivatives of the general formula (I) or pharmacologically acceptable salts thereof: (I)
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4.发明授权
公开(公告)号：EP1192950B1
公开(公告)日：2006-07-26
申请号：EP01906226.4
申请日：2001-02-22
IPC分类号： A61K45/00 , A61K31/517 , A61K31/536 , A61P43/00 , A61P17/00 , A61P17/04 , C07D239/96 , C07D401/12 , C07D403/12
CPC分类号： C07D239/96 , A61K31/00 , A61K31/517
摘要： Preventive or therapeutic drugs for dermatitises accompanied with dimorphic inflammatory reactions and those caused by repeated exposure to antigens, which inhibit the progression of such dermatitises and are so safe by virtue of their being free from adverse effects as to bring about enhancement in the quality of daily life of a patient. Specifically, remedies for the above dermatitisescontaining chymase inhibitors as the active ingredient, wherein the chymase inhibitors are quinazoline derivatives of the general formula (I) or (II) or pharmacologically acceptable salts thereof.
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