公开(公告)号：EP2714688B1

公开(公告)日：2016-02-24

申请号：EP12727936.2

申请日：2012-05-03

申请人： Daiichi Sankyo Company, Limited

发明人： VERMA, Ashwani, Kumar ,  NAGASWAMY, Kumaragurubaran ,  SHARMA, Lalima ,  GHOSH, Soma ,  KALE, Balkrishna, Ramchandra ,  MONDAL, Aniruddha ,  SRIVASTAVA, Punit, Kumar ,  DASTIDAR, Sunanda, Ghosh ,  MIYAUCHI, Rie ,  MURATA, Takeshi ,  ISHIZAKI, Masayuki ,  NAGAMOCHI, Masatoshi ,  IIMURA, Shin ,  MOMIN, Rijwan, Jaffer ,  WAGH, Pradip, Balu ,  PANSARE, Sonali, Nanasaheb ,  MARKAD, Pramod, Raosaheb ,  KHAIRNAR, Yogesh, Balasaheb

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00 ,  A61P19/00

CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D471/04

公开(公告)号：EP2714688A1

公开(公告)日：2014-04-09

申请号：EP12727936.2

申请日：2012-05-03

申请人： Daiichi Sankyo Company, Limited

发明人： VERMA, Ashwani, Kumar ,  NAGASWAMY, Kumaragurubaran ,  SHARMA, Lalima ,  GHOSH, Soma ,  KALE, Balkrishna, Ramchandra ,  MONDAL, Aniruddha ,  SRIVASTAVA, Punit, Kumar ,  DASTIDAR, Sunanda, Ghosh ,  MIYAUCHI, Rie ,  MURATA, Takeshi ,  ISHIZAKI, Masayuki ,  NAGAMOCHI, Masatoshi ,  IIMURA, Shin ,  MOMIN, Rijwan, Jaffer ,  WAGH, Pradip, Balu ,  PANSARE, Sonali, Nanasaheb ,  MARKAD, Pramod, Raosaheb ,  KHAIRNAR, Yogesh, Balasaheb

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00 ,  A61P19/00

CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D471/04

摘要： The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A' B, D, R
1 , R
2 and R
3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.