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    Blood-viscosity reducing agent
    1.
    发明公开
    Blood-viscosity reducing agent 有权
    Mittel zur Senkung derBlutviskosität

    公开(公告)号：EP1657304A1

    公开(公告)日：2006-05-17

    申请号：EP05007088.7

    申请日：2005-03-31

    申请人： Daiwa Pharmaceutical Co., Ltd ,  Hitosugi, Masahito

    发明人： Hitosugi, Masahito ,  Maeda, Hiroaki c/o Daiwa Pharmaceutical Co., Ltd. ,  Omura, Kazunobu c/o Daiwa Pharmaceutical Co., Ltd.

    IPC分类号： C12N9/56 ,  A61K38/48

    CPC分类号： C12N9/54

    摘要： A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysin, alanine, tryptophan, alanine, leucine, glycine, throsine, aspartic acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysin, glutamic acid, lysin, throsine, arginine, glycine, thyrosin, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, throsine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, thyrosin, aspartic acid, aspartic acid, leucine, alanine, histidine, glycine, threonine, histidine, valine, and threonine, a second structural amino acid sequence having alanine, phenylalanine, serine, glutamic acid, aspartic acid, glycine, glycine, threonine, aspartic acid, alanine, aspartic acid, isoleucine, leucine, glutamic acid, alanine, glycine, glutamic acid, tryptophan, valine, and leucine, a third structural amino acid sequence having aspartic acid, alanine, glutamic acid, glycine, asparagine, proline, histidine, proline, glutamic acid, methionine, alanine, proline, aspartic acid, and valine, and a fourth structural amino acid sequence having valine, proline, glycine, glutamine, alanine, thyrosin, glutamic acid, aspartic acid, glycine, tryptophan, and aspartic acid, thereby reducing the viscosity of whole blood.

    摘要翻译： 血液粘度降低剂含有源自枯草芽孢杆菌纳豆的蛋白质，从氨基末端依次包含具有丙氨酸，苏氨酸，天冬氨酸，甘氨酸，缬氨酸，谷氨酸，色氨酸，天冬酰胺，缬氨酸的第一结构氨基酸序列 ，天冬氨酸，谷氨酰胺，异亮氨酸，天冬氨酸，丙氨酸，脯氨酸，赖氨酸，丙氨酸，色氨酸，丙氨酸，亮氨酸，甘氨酸，酪氨酸，天冬氨酸，甘氨酸，苏氨酸，甘氨酸，苏氨酸，缬氨酸，缬氨酸，丙氨酸，丝氨酸，异亮氨酸， 天冬氨酸，苏氨酸，甘氨酸，缬氨酸，谷氨酸，色氨酸，天冬酰胺，组氨酸，脯氨酸，丙氨酸，亮氨酸，赖氨酸，谷氨酸，赖氨酸，酪氨酸，精氨酸，甘氨酸，甲状腺素，天冬酰胺，脯氨酸，谷氨酸，天冬酰胺， 天冬酰胺，谷氨酸，脯氨酸，谷氨酸，天冬酰胺，谷氨酸，甲硫氨酸，天冬酰胺，色氨酸，酪氨酸，天冬氨酸，丙氨酸，缬氨酸，丙氨酸，甘氨酸，谷氨酸，丙氨酸，丝氨酸，脯氨酸，甲状腺素 氨基酸，天冬氨酸，亮氨酸，丙氨酸，组氨酸，甘氨酸，苏氨酸，组氨酸，缬氨酸和苏氨酸，具有丙氨酸，苯丙氨酸，丝氨酸，谷氨酸，天冬氨酸，甘氨酸，甘氨酸，苏氨酸，天冬氨酸的第二结构氨基酸序列 ，丙氨酸，天冬氨酸，异亮氨酸，亮氨酸，谷氨酸，丙氨酸，甘氨酸，谷氨酸，色氨酸，缬氨酸和亮氨酸，具有天冬氨酸，丙氨酸，谷氨酸，甘氨酸，天冬酰胺，脯氨酸，组氨酸， 脯氨酸，谷氨酸，甲硫氨酸，丙氨酸，脯氨酸，天冬氨酸和缬氨酸，以及具有缬氨酸，脯氨酸，甘氨酸，谷氨酰胺，丙氨酸，甲状腺素，谷氨酸，天冬氨酸，甘氨酸，色氨酸和天冬氨酸的第四结构氨基酸序列 ，从而降低全血的粘度。