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1.
公开(公告)号:EP2208061B1
公开(公告)日:2017-11-08
申请号:EP08834506.1
申请日:2008-09-26
发明人: WALENSKY, Loren, D. , TJANDRA, Nico , GAVATHIOTIS, Evripidis , SUZUKI, Motoshi , BIRD, Gregory, H.
CPC分类号: G01N33/5079 , C07K14/4747 , G01N33/5011 , G01N33/5035 , G01N2510/00
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2.METHODS AND COMPOSITIONS FOR MODULATING BCL-2 FAMILY POLYPEPTIDES 有权
标题翻译: VERFAHREN UND ZUSAMMENSETZUNGEN ZUR MODULATION VON POLYPEPTIDEN DER BCL-2-FAMILIE公开(公告)号:EP2208061A2
公开(公告)日:2010-07-21
申请号:EP08834506.1
申请日:2008-09-26
发明人: WALENSKY, Loren, D. , TJANDRA, Nico , GAVATHIOTIS, Evripidis , SUZUKI, Motoshi , BIRD, Gregory, H.
CPC分类号: G01N33/5079 , C07K14/4747 , G01N33/5011 , G01N33/5035 , G01N2510/00
摘要: The present invention is based, at least in part, on the identification of a novel active site on BCL-2 family polypeptide such as BAX, which when bound by a compound, modifies the activity of the BCL-2 family polypeptide.
摘要翻译: 本发明至少部分地基于BCL-2家族多肽如BAX上的新活性位点的鉴定,当被化合物结合时,其修饰BCL-2家族多肽的活性。
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