公开(公告)号：EP3503924A2

公开(公告)日：2019-07-03

申请号：EP17771914.3

申请日：2017-08-25

申请人： Dana-Farber Cancer Institute, Inc. ,  President and Fellows of Harvard College

发明人： SEGAL, Rosalind ,  WALENSKY, Loren D. ,  GOODRICH, Lisa Vaughn ,  RAISSI, Sarah Elizabeth ,  MURPHY, Maria F. ,  BIRD, Gregory H.

IPC分类号： A61K45/06 ,  A61K31/337 ,  C07K14/47 ,  A61P25/02 ,  A61P25/00 ,  A61P27/16

公开(公告)号：EP2118123B1

公开(公告)日：2015-10-14

申请号：EP08728649.8

申请日：2008-01-31

申请人： Dana-Farber Cancer Institute, Inc. ,  President and Fellows of Harvard College

发明人： BERNAL, Federico ,  WALENSKY, Loren D. ,  VERDINE, Gregory L. ,  KORSMEYER, Stanley

IPC分类号： C07K7/54 ,  C07K14/47

CPC分类号： C07K14/4746 ,  A61K38/00 ,  C07K1/113

公开(公告)号：EP2118123A1

公开(公告)日：2009-11-18

申请号：EP08728649.8

申请日：2008-01-31

申请人： Dana-Farber Cancer Institute, Inc. ,  President and Fellows of Harvard College

发明人： BERNAL, Federico ,  WALENSKY, Loren D. ,  VERDINE, Gregory L. ,  KORSMEYER, Stanley

IPC分类号： C07K7/54

CPC分类号： C07K14/4746 ,  A61K38/00 ,  C07K1/113

摘要： Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying therapeutic agents that binding to HMD2 or a family member of HDM2.

公开(公告)号：EP4399220A1

公开(公告)日：2024-07-17

申请号：EP22785887.5

申请日：2022-09-08

申请人： Dana-Farber Cancer Institute, Inc.

发明人： WALENSKY, Loren D. ,  BIRD, Gregory H.

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K47/10 ,  A61K47/28 ,  A61P31/14 ,  A61K47/60

CPC分类号： C07K14/005 ,  C12N2770/2002220130101 ,  C12N2770/2003420130101 ,  A61K39/12 ,  A61P31/14 ,  A61K47/554 ,  A61K2039/601820130101 ,  A61K2039/609320130101 ,  A61K9/0073 ,  A61K9/0043 ,  A61K9/006

公开(公告)号：EP2970418A2

公开(公告)日：2016-01-20

申请号：EP14767620.9

申请日：2014-03-13

申请人： Dana-Farber Cancer Institute, Inc.

发明人： WALENSKY, Loren D.

IPC分类号： C07K14/47 ,  A61K38/17

CPC分类号： C12N9/96 ,  A61K38/00 ,  C07K14/47 ,  C12N9/1007 ,  C12Y201/01043

摘要： Provided herein are polypeptides containing stabilized therapeutic peptides related to enhancer of zeste homolog 2 (EZH2), histone lysine N-methyltransferase. Also provided are compositions containing these polypeptides and methods of using such peptides in the treatment of cancer that include administering to a subject one of the polypeptides.

公开(公告)号：EP2766355A2

公开(公告)日：2014-08-20

申请号：EP12840731.9

申请日：2012-10-11

申请人： Dana-Farber Cancer Institute, Inc.

发明人： WALENSKY, Loren D.

IPC分类号： C07D403/04 ,  C07D417/04 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D417/04 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/497 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D417/14

摘要： This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).

公开(公告)号：EP3962933A1

公开(公告)日：2022-03-09

申请号：EP20725283.4

申请日：2020-04-17

申请人： Dana-Farber Cancer Institute, Inc.

发明人： WALENSKY, Loren D. ,  CATHCART, Ann Morgan ,  BIRD, Gregory H.

IPC分类号： C07K14/47

公开(公告)号：EP3765852A1

公开(公告)日：2021-01-20

申请号：EP19717637.3

申请日：2019-03-14

申请人： Dana Farber Cancer Institute, Inc.

发明人： WALENSKY, Loren D. ,  HERCE, Henry D. ,  MOURTADA, Rida

IPC分类号： G01N33/53

公开(公告)号：EP3715366A1

公开(公告)日：2020-09-30

申请号：EP20172306.1

申请日：2012-04-16

申请人： Dana Farber Cancer Institute, Inc.

发明人： WALENSKY, Loren D. ,  CARRASCO, Ruben ,  BIRD, Gregory H.

IPC分类号： C07K14/47 ,  A61K38/17 ,  A61P35/00

摘要： The invention provides structurally-constrained peptides by hydrocarbon stapling of a BCL9 HD2 helix for use as a therapeutic agent. The invention further provides methods and kits for use of the structurally-constrained peptide of the instant invention. The invention is based, at least in part, on the results provided herein demonstrating that hydrocarbon stapled helical peptides display excellent proteolytic, acid, and thermal stability, restore the native helical structure of the peptide, possess superior pharmacokinetic properties compared to the corresponding unmodified peptides, and are highly effective in binding to ß-catenin in vitro, in cellulo, and in vivo, disrupting the BCL-9/ß-catenin interaction, and thereby interfering with deregulated Wnt/ß-catenin signaling for therapeutic benefit in a variety of human diseases including human cancer.

公开(公告)号：EP4228699A1

公开(公告)日：2023-08-23

申请号：EP21811174.8

申请日：2021-10-14

申请人： Dana-Farber Cancer Institute, Inc.

发明人： HERCE, Henry D. ,  WALENSKY, Loren D.

IPC分类号： A61K47/55 ,  A61K47/64 ,  C07K7/00 ,  A61P31/14