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公开(公告)号：EP3866809A1
公开(公告)日：2021-08-25
申请号：EP19874207.4
申请日：2019-10-16
发明人： GRAY, Nathanael S. , HATCHER, John , CHOI, Jieun , CHOI, Hwangeun , KO, Eunhwa , KIM, Namdoo
IPC分类号： A61K31/541 , A61P11/00 , C07D471/04
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公开(公告)号：EP3968990A1
公开(公告)日：2022-03-23
申请号：EP20804945.2
申请日：2020-05-15
发明人： GRAY, Nathanael S. , HATCHER, John , CHOI, Jieun , LEE, Sun-Hwa , CHOI, Hwangeun , KO, Eunhwa , KIM, Yeonsil , KIM, Daekwon , KIM, Namdoo , SON, Jungbeom
IPC分类号： A61K31/437 , C07D487/04 , A61P25/28
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公开(公告)号：EP4341254A1
公开(公告)日：2024-03-27
申请号：EP22805453.2
申请日：2022-05-19
发明人： GRAY, Nathanael S. , TENG, Mingxing , WANG, Eric , JIANG, Jie , ZHANG, Tinghu , CANTLEY, Lewis C. , FISCHER, Eric S. , DONOVAN, Katherine A.
IPC分类号： C07D403/12 , C07D403/14 , C07D417/14
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公开(公告)号：EP4225300A1
公开(公告)日：2023-08-16
申请号：EP21878296.9
申请日：2021-10-04
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/519 , C07D207/04 , C07D487/00 , C07D487/04
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公开(公告)号：EP4058015A1
公开(公告)日：2022-09-21
申请号：EP20888144.1
申请日：2020-11-11
发明人： SCOTT, David A. , HEPPNER, David , GERO, Thomas , CULLIS, Courtney A. , TO, Ciric , HUANG, Shih-Chung , HU, Yongbo , STROUD, Steve , BEYETT, Tyler , ECK, Michael , GRAY, Nathanael S.
IPC分类号： A61K31/395 , A61K31/435 , A61K31/4353 , C07D253/00 , C07D471/02 , C07D471/04
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公开(公告)号：EP4051386A1
公开(公告)日：2022-09-07
申请号：EP20882103.3
申请日：2020-10-29
发明人： GRAY, Nathanael S. , LIU, Hu , ZHANG, Tinghu , JONES, Lyn Howard , CHE, Jianwei
IPC分类号： A61P35/00 , C07D401/04 , C07D401/14
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公开(公告)号：EP4047001A2
公开(公告)日：2022-08-24
申请号：EP21218204.2
申请日：2017-07-05
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
发明人： GRAY, Nathanael S. , LIANG, Yanke , CHOI, Hwan Geun , SUNDBERG, Thomas , SHAMJI, Alykhan , XAVIER, Ramnik , FISHER, David E. , MUJAHID, Nisma
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P7/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P37/00
摘要： The present disclosure provides compounds of Formula ( I ), ( II ), and ( III ). The provided compounds are able to bind protein kinases ( e . g ., SIK) and may be useful in modulating ( e.g., inhibiting) the activity of a protein kinase ( e.g., SIK, ( e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease ( e . g ., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
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公开(公告)号：EP3828185A3
公开(公告)日：2021-09-01
申请号：EP21152496.2
申请日：2010-01-06
IPC分类号： C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D513/04 , A61P35/00 , A61P29/00 , A61K31/4985 , A61K31/519
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1,2,3, or 4, Ackl, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rskl, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3866801A1
公开(公告)日：2021-08-25
申请号：EP19873444.4
申请日：2019-10-16
发明人： GRAY, Nathanael S. , HATCHER, John
IPC分类号： A61K31/454
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公开(公告)号：EP3807253A1
公开(公告)日：2021-04-21
申请号：EP19820366.3
申请日：2019-06-14
发明人： GRAY, Nathanael S. , JANG, Jaebong , JANNE, Pasi , SON, Jieun
IPC分类号： C07D239/94 , C07D401/12 , C07D405/12
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