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    CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES
    3.
    发明公开
    CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES 有权
    CYCLOPROPANAMIDE和模拟具有抗癌特性和抗增殖特性

    公开(公告)号：EP2365752A1

    公开(公告)日：2011-09-21

    申请号：EP09824132.6

    申请日：2009-10-29

    申请人： Deciphera Pharmaceuticals, Llc

    发明人： FLYNN, Daniel, L. ,  PETILLO, Peter, A. ,  KAUFMAN, Michael, D.

    IPC分类号： A01N43/90 ,  A01N55/02 ,  A61K31/555

    CPC分类号： C07D413/04 ,  A61K31/555 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

    摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.

    KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES
    5.
    发明公开
    KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES 审中-公开
    激酶抑制剂用于治疗增生性疾病和其他增殖性疾病

    公开(公告)号：EP2148677A1

    公开(公告)日：2010-02-03

    申请号：EP08746333.7

    申请日：2008-04-18

    申请人： Deciphera Pharmaceuticals, LLC.

    发明人： FLYNN, Daniel, L. ,  PETILLO, Peter, A. ,  KAUFMAN, Michael, D.

    IPC分类号： A61K31/519 ,  A61K31/444 ,  C07D239/70 ,  C07D401/12

    CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

    摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers. breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, a disease caused by c-Abl kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, a disease caused by c-Kit kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, a disease caused by c-Met kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, or a disease caused by a Raf kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof.

    摘要翻译： 本发明化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性黑素瘤，实体瘤，成胶质细胞瘤，卵巢癌，胰腺癌，前列腺癌，肺癌。 乳腺癌，肾癌，肝癌，宫颈癌，原发性肿瘤部位的转移，骨髓增殖性疾病，慢性骨髓性白血病，白血病，乳头状甲状腺癌，非小细胞肺癌，间皮瘤，嗜酸性粒细胞增多综合征，胃肠道间质瘤，结肠癌， 以过度增殖为特征的眼病包括各种视网膜病，糖尿病视网膜病，类风湿性关节炎，哮喘，慢性阻塞性肺病，肥大细胞增多症，肥大细胞白血病，由c-Abl激酶引起的疾病，其致癌形式，其异常融合蛋白和多晶型物 由c-Kit激酶引起的疾病，其致癌形式，其异常融合蛋白及其多形体，由c-Met激酶引起的疾病，其致癌形式，其异常融合蛋白及其多晶型，或由 Raf激酶，其致癌形式，其异常融合蛋白， d多晶型物。

    KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES
    6.
    发明公开
    KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES 审中-公开
    激酶抑制剂用于治疗增生性疾病和其他增殖性疾病

    公开(公告)号：EP2146718A1

    公开(公告)日：2010-01-27

    申请号：EP08746306.3

    申请日：2008-04-18

    申请人： Deciphera Pharmaceuticals, LLC.

    发明人： FLYNN, Daniel, L. ,  PETILLO, Peter, A. ,  KAUFMAN, Michael, D.

    IPC分类号： A61K31/506 ,  A61K31/517 ,  A61K31/426 ,  A61K31/433 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

    CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

    摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant, melanomas, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, leukemias, papillary thyroid carcinoma, non small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocyctosis, mast cell leukemia, a disease caused by c-Abl kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, or a disease caused by c-Kit kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof.

    摘要翻译： 本发明化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性肿瘤，黑素瘤，成胶质细胞瘤，卵巢癌，胰腺癌，前列腺癌，肺癌，乳腺癌，肾癌，宫颈癌，转移瘤 原发性肿瘤位点，骨髓增殖性疾病，白血病，乳头状甲状腺癌，非小细胞肺癌，间皮瘤，嗜酸性粒细胞增多综合征，胃肠道间质瘤，结肠癌，以过度增殖为特征的眼病，导致包括各种视网膜病，类风湿性关节炎，哮喘，慢性 阻塞性肺病，肥大细胞增多症，肥大细胞白血病，由c-Abl激酶引起的疾病，其致癌形式，其异常融合蛋白及其多态性，或由c-Kit激酶引起的疾病，致癌形式，其异常融合蛋白和 多晶型物。

    KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES
    9.
    发明公开
    KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES 审中-公开
    激酶抑制剂用于治疗增生性疾病和其他增殖性疾病

    公开(公告)号：EP2146717A1

    公开(公告)日：2010-01-27

    申请号：EP08746294.1

    申请日：2008-04-18

    申请人： Deciphera Pharmaceuticals, LLC.

    发明人： FLYNN, Daniel, L. ,  PETILLO, Peter, A. ,  KAUFMAN, Michael, D.

    IPC分类号： A61K31/506 ,  A61K31/517 ,  A61K31/426 ,  A61K31/433 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

    CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

    摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant, melanomas, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, leukemias, papillary thyroid carcinoma, non small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, a disease caused by c-Abl kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, or a disease caused by c-Kit kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof.

    摘要翻译： 本发明化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性肿瘤，黑素瘤，成胶质细胞瘤，卵巢癌，胰腺癌，前列腺癌，肺癌，乳腺癌，肾癌，宫颈癌，转移瘤 原发性肿瘤位点，骨髓增殖性疾病，白血病，乳头状甲状腺癌，非小细胞肺癌，间皮瘤，嗜酸性粒细胞增多综合征，胃肠道间质瘤，结肠癌，以过度增殖为特征的眼病，导致包括各种视网膜病，类风湿性关节炎，哮喘，慢性 肥大细胞白血病，由c-Abl激酶引起的疾病，其致癌形式，其异常融合蛋白及其多形体，或由c-Kit激酶引起的疾病，其致癌形式，其异常融合蛋白和 多晶型物。