JANUS DENDRIMERS AND DENDRONS
    4.
    发明公开
    JANUS DENDRIMERS AND DENDRONS 有权
    JANUS树枝状和-DENDRONE

    公开(公告)号:EP1869106A2

    公开(公告)日:2007-12-26

    申请号:EP06748759.5

    申请日:2006-03-27

    CPC分类号: C08G83/003 C08G81/00

    摘要: This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which may be used as intermediates to make the Janus dendrimers or to further react with another reactive moiety. These Janus dendrimers can provide several new dendrimer moieties, namely: combinatorial libraries of bifunctional structures; combined target director and signaling dendrimers; specific targeting entities for diagnostic and therapeutic applications, such as for example targeted MRI agents, targeted radionuclide delivery for diseases such as cancer, and targeted photosensitive or radiowave sensitive agents.