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1.发明授权
公开(公告)号：EP1140977B1
公开(公告)日：2005-03-09
申请号：EP99965395.9
申请日：1999-12-14
申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts , Europäisches Laboratorium für Molekularbiologie
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6428
摘要： According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90 °C, preferably below 50 °C. The substances that are embedded in the matrix form transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90 °C, preferably below 50 °C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilised by modifying their physical environment and brought into the vicinity of the support surface through a physical process. Here, the substances link up with the molecules. This method can be repeated to apply multiple layers to the support in precise positions. The method can be carried out using a device which essentially has the structure of a laser printer or a laser copier or an ink-jet printer.
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2.发明公开
公开(公告)号：EP1140977A2
公开(公告)日：2001-10-10
申请号：EP99965395.9
申请日：1999-12-14
申请人： Deutsches KrebsforschungszentrumStiftung des öffentlichen Rechts , Europäisches Laboratorium für Molekularbiologie
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6428
摘要： According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90 °C, preferably below 50 °C. The substances that are embedded in the matrix form transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90 °C, preferably below 50 °C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilised by modifying their physical environment and brought into the vicinity of the support surface through a physical process. Here, the substances link up with the molecules. This method can be repeated to apply multiple layers to the support in precise positions. The method can be carried out using a device which essentially has the structure of a laser printer or a laser copier or an ink-jet printer.
摘要翻译： 。根据本发明的方法用于将物质到支撑，爱特别是对于分子库的组合合成单体时，物质被第一个嵌入在基质中的至少一种溶剂由......组成，所述溶剂在温度低于在聚集的固体状态 90℃，优选低于50℃。将物质没有被嵌入在从随后被施加到支撑在聚合的固态运输单元的矩阵，在低于90℃的温度，优选低于50℃ 或者，所述传送单元可以与第二溶剂部分溶解并在聚集的液体状态，在那里它们通过后所述溶剂部分聚集的固体或凝胶状阶段已经完全呼叫或部分蒸发施加到支撑。 在基质中的物质，然后通过修改它们的物理环境动员，并且通过物理过程带入支撑表面的附近。 在这里，物质联系起来与分子。 这种方法可以被重复以多个层施加到在精确位置上的支持。 该方法可以使用，其基本上具有激光打印机或激光复印机或喷墨打印机的结构的装置来进行。
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