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公开(公告)号：EP1243655B1
公开(公告)日：2007-02-21
申请号：EP01107271.7
申请日：2001-03-23
IPC分类号： C12N15/62 , C07K19/00 , C07K14/025 , C07K16/08 , A61K31/7088 , A61K38/16 , G01N33/53 , A01K67/00
CPC分类号： G01N33/56983 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C07K2319/43 , C12N7/00 , C12N15/62 , C12N2710/20022 , C12N2710/20034
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2.发明公开Modified HPV E6 and E7 genes and proteins useful for vaccination 有权Modifizierte HPV E6-和E7-基因和-Proteine als Impfstoff
公开(公告)号：EP1243655A1
公开(公告)日：2002-09-25
申请号：EP01107271.7
申请日：2001-03-23
IPC分类号： C12N15/62 , C07K19/00 , C07K14/025 , C07K16/08 , A61K31/7088 , A61K38/16 , G01N33/53 , A01K67/00
CPC分类号： G01N33/56983 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C07K2319/43 , C12N7/00 , C12N15/62 , C12N2710/20022 , C12N2710/20034
摘要： Described are DNA sequences encoding an E6 or E7 fusionprotein of HPV, wherein said DNA sequences are characterized by a combination of the following features: original codons are exchanged by codons which lead to an enhanced translation in a mammalian cell, they contain a deletion resulting in the production of a truncated non-functional protein, and they encode a fusionpartner which is a highly immunogenic polypeptide capable of enhancing the immunogenicity of the E6 or E7 protein in the mammalian host. Furthermore, the modified E6 or E7 protein encoded by said DNA sequences as well as expression vectors containing said DNA sequences are described as well as several uses of the these compounds.
摘要翻译： 描述了编码HPV的E6或E7融合蛋白的DNA序列，其中所述DNA序列的特征在于以下特征的组合：原始密码子由密码子交换，导致哺乳动物细胞中的翻译增强，它们含有缺失，导致 生产截短的非功能性蛋白质，并且它们编码能够增强哺乳动物宿主中E6或E7蛋白的免疫原性的高度免疫原性多肽的融合蛋白家族。 此外，描述了由所述DNA序列编码的修饰的E6或E7蛋白以及含有所述DNA序列的表达载体以及这些化合物的几种用途。
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