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1.发明授权
公开(公告)号：EP1608349B1
公开(公告)日：2007-10-17
申请号：EP04757724.2
申请日：2004-03-17
发明人： PENHASI, Adel , REUVENI, Albert , OREN, Dan
IPC分类号： A61K9/70 , A61K31/19 , A61K31/155 , A61P29/00
CPC分类号： A61K9/0024 , A61K9/0063 , A61K9/7007 , A61K31/155 , A61K31/19 , A61K45/06 , A61K2300/00
摘要： The present invention provides an oral delivery system for the treatment of periodontal disease, being in a solid unit dosage form for administration to a patient and comprising: (i) a biodegradable or bioerodible pharmaceutically acceptable polymer; (ii) a therapeutically effective amount of at least one antibacterial agent; and (iii) a therapeutically effective amount of at least one anti-inflammatory agent, the relative weight ratio between the antibacterial agent and the anti-inflammatory agent ranking from about 7:1 to about 1:5. The system may further comprise at least one of a cross-linking agent, a plasticizing agent, a wetting agent, a suspending agent, a surfactant and a dispersing agent.
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2.发明公开
公开(公告)号：EP1608349A1
公开(公告)日：2005-12-28
申请号：EP04757724.2
申请日：2004-03-17
发明人： PENHASI, Adel , REUVENI, Albert , OREN, Dan
IPC分类号： A61K9/70 , A61K31/19 , A61K31/155 , A61P29/00
CPC分类号： A61K9/0024 , A61K9/0063 , A61K9/7007 , A61K31/155 , A61K31/19 , A61K45/06 , A61K2300/00
摘要： The present invention provides an oral delivery system for the treatment of periodontal disease, being in a solid unit dosage form for administration to a patient and comprising: (i) a biodegradable or bioerodible pharmaceutically acceptable polymer; (ii) a therapeutically effective amount of at least one antibacterial agent; and (iii) a therapeutically effective amount of at least one anti-inflammatory agent, the relative weight ratio between the antibacterial agent and the anti-inflammatory agent ranking from about 7:1 to about 1:5. The system may further comprise at least one of a cross-linking agent, a plasticizing agent, a wetting agent, a suspending agent, a surfactant and a dispersing agent.
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