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公开(公告)号:EP2432767A1
公开(公告)日:2012-03-28
申请号:EP10720212.9
申请日:2010-05-03
申请人: Dow AgroSciences LLC
发明人: DAVIS, George , LO, William , RENGA, James , TISDELL, Francis , YAP, Maurice , YOUNG, David
IPC分类号: C07D239/30 , A01N43/54 , A01P3/00
CPC分类号: A61K31/505 , A01N43/54 , C07D239/30
摘要: Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula (I), wherein, X
1 is N or C-R
3 ; X
2 is N or C-R
4 provided that X
1 and X
2 are not both N; R
1 -R
7 are H, CN, CHO, -SCN, NO
2 , F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, Cl-C4-alkoxy-amino, C1-C4-alkyl-S(O)=NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO
2 , CHO, -SCN, S(0)n-C1-C4-alkyl (where n = 0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-thioalkyl, halo-C1-C4-thioalkyl, C1-C4-alkylacyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-imino, hydroxy- imino; C1-C4-alkyl-S(O)=NH; and Q is a substituted or unsubstituted aryl, substituted or unsubstituted heterocycle wherein the substituents of Q are taken from R
1 -R
7 .摘要翻译: 本文公开的各个方面涉及根据式(I)的芳基取代的氨基嘧啶,其中X 1是N或C-R 3; X 2是N或C-R 4,条件是X 1和X 2不都是N; R 1 -R 7是H,CN,CHO,-SCN,NO 2,F,Cl,Br,I,取代或未取代的C 1 -C 4烷基,取代或未取代的卤代C 1 -C 4烷基, 取代或未取代的卤代-C 1 -C 4 - 烷氧基,取代或未取代的卤代-C 1 -C 4 - 烷氧基,取代或未取代的C 1 -C 4 - 硫代烷基,取代或未取代的C 3 -C 7 - C2-C4-链烯基,C2-C4-炔基,取代的或未取代的C1-C4-酰基烷基,C1-C4-酰氧基,C1-C4-烷氧基羰基,C1- = NH,取代或未取代的芳基,取代或未取代的杂环,其中取代基为以下一个或多个F,Cl,Br,OH,CN,NO 2,CHO,-SCN,S(O)n -C 1 -C 4 (其中n = 0-2),C 1 -C 4烷基,卤代C 1 -C 4烷基,C 1 -C 4烷基胺,C 1 -C 4烷氧基,卤代C 1 -C 4烷氧基,C 1 -C 4硫代烷基 卤代-C 1 -C 4硫代烷基,C 1 -C 4烷基酰基,C 1 -C 4酰氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基亚氨基,羟基亚氨基; C1-C4烷基-S(O)= NH; Q是取代或未取代的芳基,取代或未取代的杂环,其中Q的取代基取自R 1 -R 7。
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公开(公告)号:EP2432767B1
公开(公告)日:2013-06-26
申请号:EP10720212.9
申请日:2010-05-03
申请人: Dow AgroSciences LLC
发明人: DAVIS, George , LO, William , RENGA, James , TISDELL, Francis , YAP, Maurice , YOUNG, David
IPC分类号: C07D239/30 , A01N43/54 , A01P3/00
CPC分类号: A61K31/505 , A01N43/54 , C07D239/30
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公开(公告)号:EP2427191B1
公开(公告)日:2016-03-16
申请号:EP10772663.0
申请日:2010-05-04
申请人: Dow AgroSciences LLC
发明人: TRULLINGER, Tony , HUNTER, Ricky , GARIZI, Negar , YAP, Maurice , BUYSSE, Ann , PERNICH, Dan , JOHNSON, Timothy , BRYAN, Kristy , DEAMICIS, Carl , ZHANG, Yu , NIYAZ, Noormohamed , MCLEOD, CaSandra , ROSS, Ronald , ZHU, Yuanming , JOHNSON, Peter , ECKELBARGER, Joseph , PARKER, Marshall
IPC分类号: A61K31/44 , C07D417/04 , C07D417/14
CPC分类号: A01N43/78 , A01N43/40 , C07D417/04 , C07D417/14
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公开(公告)号:EP2427191A1
公开(公告)日:2012-03-14
申请号:EP10772663.0
申请日:2010-05-04
申请人: Dow AgroSciences LLC
发明人: TRULLINGER, Tony , HUNTER, Ricky , GARIZI, Negar , YAP, Maurice , BUYSSE, Ann , PERNICH, Dan , JOHNSON, Timothy , BRYAN, Kristy , DEAMICIS, Carl , ZHANG, Yu , NIYAZ, Noormohamed , MCLEOD, CaSandra , ROSS, Ronald , ZHU, Yuanming , JOHNSON, Peter , ECKELBARGER, Joseph , PARKER, Marshall
IPC分类号: A61K31/44
CPC分类号: A01N43/78 , A01N43/40 , C07D417/04 , C07D417/14
摘要: This document discloses molecules having the following formula (see "Formula I").
摘要翻译: 该文献公开了具有下式的分子(参见“式I”)。
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