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    Quinazoline derivatives
    1.
    发明公开
    Quinazoline derivatives 失效
    Chinazolin衍。

    公开(公告)号：EP0326329A2

    公开(公告)日：1989-08-02

    申请号：EP89300657.7

    申请日：1989-01-25

    申请人： DowElanco

    发明人： Dreikorn, Barry Allen ,  Suhr, Robert George ,  Jourdan, Glen Phil ,  Wright, Ian Glaisby

    IPC分类号： C07D239/94 ,  C07D409/06 ,  C07D239/88 ,  C07D239/74 ,  A01N43/54 ,  C07D409/12

    CPC分类号： C07D405/06 ,  A01N43/54 ,  C07D239/74 ,  C07D239/88 ,  C07D239/94 ,  C07D239/95 ,  C07D409/06

    摘要： Substituted quinazolines of the formula (1):
    wherein:

    R 1 to R 4 are independently H, halo, (Ci-C 4 ) alkyl, branched (C 3 -C 4 ) alkyl, halo (C 1 -C 4 ) alkyl, (Ci-C 4 ) alkoxy, N0 2 , or NH 2 , provided that
    at least two of R 1 to R 4 are H;
    Y is H, Cl, X-W-Ar, or O-Alk;
    X is 0, NR 7 , or CR8 R 9;
    Z is H, Cl, OCH 3 , CH 3 , or -NR 7- W-Ar, provided that Z can be -NR 7 -W-Ar only if Y is H, Cl, or NR 7 -W-Ar and Z must be -NR 7- W-Ar if Y is H or Cl;
    R 7 is H, (C 1 -C 4 ) alkyl, or acetyl;
    R 8 and R9 are independently H, (C 1 -C 4 ) alkyl, halo, or OH;
    W is an alkylene chain 2 to 6 carbon atoms long, optionally including a carbocyclic ring or substituted with (C 1 -C 3 ) alkyl, phenyl, (C 3 -C 8 ) cycloalkyl, halo, hydroxy, or acetyl; and Ar is
    imidazolyl;
    indolyl;
    thienyl, optionally substituted with CH 3 or Cl;
    thiazolyl;
    1,3-benzodioxolyl;
    fluorenyl;
    cyclohexyl (hexahydrophenyl),
    cyclohexenyl (tetrahydrophenyl),
    naphthyl,
    dihydronaphthyl,
    tetrahydronaphthyl,
    decahydronaphthyl;

    or a group of the formula (2):
    where

    R 10 to R 14 are independently H, halo, I, (C 1 -C 10 ) alkyl, branched (C 3 -C 6 ) alkyl, halo (C 1 -C 4 ) alkyl, (Ci-C 4 ) alkoxy, halo (C 1 -C 4 ) alkoxy, phenoxy, substituted phenoxy, phenyl, substituted phenyl, phenylthio, substituted phenylthio, NH 2 , N0 2 , OH, or CN, at least two R 1 to R 4 being H;
    Alk is (C 2 -C 18 ) alkyl, straight chain or branched;

    or an acid addition salt of a compound of formula (1) provided that:

    if R 1 to R 4 are all H and Y is NR 7- W-Ar, then Ar is naphthyl or a group of formula (2) wherein at least one of R 10 to R 14 is phenyl, substituted phenyl, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, halo (C 1 -C 4 ) alkyl, or halo (C 1 -C 4 ) alkoxy are plant fungicides, miticides, and insecticides.

    摘要翻译： 式（1）的取代喹唑啉：其中：R 1至R 4独立地为H，卤素，（C 1 -C 4）烷基，支链（C 3 -C 4）烷基，卤代（C 1 -C 4） 烷基，（C 1 -C 4）烷氧基，NO 2或NH 2，条件是R 1至R 4中的至少两个为H; Y是H，Cl，X-W-Ar或O-Alk; X是O，NR 7或CR 8 R 9; Z是H，Cl，OCH 3，CH 3或-NR 7 -W-Ar，条件是只有当Y是H，Cl或NR 7 -W时，Z可以是-NR 7 -W-Ar 如果Y是H或Cl，-Ar和Z必须是-NR 7 -W-Ar; R 7是H，（C 1 -C 4）烷基或乙酰基; R 8和R 9独立地为H，（C 1 -C 4）烷基，卤素或OH; W是长度为2至6个碳原子的亚烷基链，任选地包括碳环或被（C 1 -C 3）烷基取代，苯基，（C 3 -C 8）环烷基，卤素，羟基或乙酰基; 和Ar是咪唑基; 吲哚基; 任选被CH 3或Cl取代的噻吩基; 噻唑基; 1,3-苯并二氧杂环戊; 芴; 环己基（六氢苯基），环己烯基（四氢苯基），萘基，二氢萘基，四氢萘基，十氢萘基; 或者式（2）的基团：其中R 1至O 1至R 4独立地为H，卤素，I，（C 1 -C 10）烷基，支链（C 3 -C 6） 烷基，卤代（C 1 -C 4）烷基，（C 1 -C 4）烷氧基，卤代（C 1 -C 4）烷氧基，苯氧基，取代的苯氧基，苯基，取代的苯基，苯硫基，取代的苯硫基，NH 2，NO 2，OH或CN 至少两个R 1至R 4为H; Alk是（C2-C18）烷基，直链或支链; 或式（1）化合物的酸加成盐，其条件是：如果R 1至R 4均为H且Y为NR 7 -W-Ar，则Ar为萘基或式 （2）其中R 1至O 4至4中的至少一个为苯基，取代的苯基，苯氧基，取代的苯氧基，苯硫基，取代的苯硫基，卤代（C 1 -C 4）烷基或卤代（ C1-C4）烷氧基是植物杀真菌剂，杀螨剂和杀虫剂。

    Quinazoline derivatives
    4.
    发明公开
    Quinazoline derivatives 失效
    喹诺酮衍生物

    公开(公告)号：EP0326329A3

    公开(公告)日：1990-09-12

    申请号：EP89300657.7

    申请日：1989-01-25

    申请人： DowElanco

    发明人： Dreikorn, Barry Allen ,  Suhr, Robert George ,  Jourdan, Glen Phil ,  Wright, Ian Glaisby

    IPC分类号： C07D239/94 ,  C07D409/06 ,  C07D239/88 ,  C07D239/74 ,  A01N43/54 ,  C07D409/12

    CPC分类号： C07D405/06 ,  A01N43/54 ,  C07D239/74 ,  C07D239/88 ,  C07D239/94 ,  C07D239/95 ,  C07D409/06

    摘要： Substituted quinazolines of the formula (1):
    wherein:
    R 1 to R 4 are independently H, halo, (Ci-C 4 ) alkyl, branched (C 3 -C 4 ) alkyl, halo (C 1 -C 4 ) alkyl, (Ci-C 4 ) alkoxy, N0 2 , or NH 2 , provided that at least two of R 1 to R 4 are H; Y is H, Cl, X-W-Ar, or O-Alk; X is 0, NR 7 , or CR8 R 9; Z is H, Cl, OCH 3 , CH 3 , or -NR 7- W-Ar, provided that Z can be -NR 7 -W-Ar only if Y is H, Cl, or NR 7 -W-Ar and Z must be -NR 7- W-Ar if Y is H or Cl; R 7 is H, (C 1 -C 4 ) alkyl, or acetyl; R 8 and R9 are independently H, (C 1 -C 4 ) alkyl, halo, or OH; W is an alkylene chain 2 to 6 carbon atoms long, optionally including a carbocyclic ring or substituted with (C 1 -C 3 ) alkyl, phenyl, (C 3 -C 8 ) cycloalkyl, halo, hydroxy, or acetyl; and Ar is imidazolyl; indolyl; thienyl, optionally substituted with CH 3 or Cl; thiazolyl; 1,3-benzodioxolyl; fluorenyl; cyclohexyl (hexahydrophenyl), cyclohexenyl (tetrahydrophenyl), naphthyl, dihydronaphthyl, tetrahydronaphthyl, decahydronaphthyl;
    or a group of the formula (2): where
    R 10 to R 14 are independently H, halo, I, (C 1 -C 10 ) alkyl, branched (C 3 -C 6 ) alkyl, halo (C 1 -C 4 ) alkyl, (Ci-C 4 ) alkoxy, halo (C 1 -C 4 ) alkoxy, phenoxy, substituted phenoxy, phenyl, substituted phenyl, phenylthio, substituted phenylthio, NH 2 , N0 2 , OH, or CN, at least two R 1 to R 4 being H; Alk is (C 2 -C 18 ) alkyl, straight chain or branched;
    or an acid addition salt of a compound of formula (1) provided that:
    if R 1 to R 4 are all H and Y is NR 7- W-Ar, then Ar is naphthyl or a group of formula (2) wherein at least one of R 10 to R 14 is phenyl, substituted phenyl, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, halo (C 1 -C 4 ) alkyl, or halo (C 1 -C 4 ) alkoxy are plant fungicides, miticides, and insecticides.