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1.发明公开SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS 审中-公开替代性杂交氨基转移蛋白（CETP）-INHIBITOREN
公开(公告)号：EP2744803A2
公开(公告)日：2014-06-25
申请号：EP12787075.6
申请日：2012-08-17
发明人： BORUAH, Anima , ALIKUNJU, Shanavas
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , A61K31/4709 , A61K31/435 , A61P3/06
CPC分类号： A61K31/4709 , A61K31/435 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14
摘要： The present application relates to cycloalkylpyridin-2-amines derivates of formula (1) or stereoisomers thereof or pharmaceutically acceptable salts thereof. The present application also relates to the process for the preparation of compounds of formula (I). The present application further describes the compounds of formula (1) as cholesteryl ester-transfer protein (CETP) inhibitors. The present application further relates to pharmaceutical compositions comprising compounds of formula (1) or stereoisomers thereof or pharmaceutically acceptable salts thereof.
摘要翻译： 本申请涉及式（1）的环烷基吡啶-2-胺衍生物或其立体异构体或其药学上可接受的盐。 本申请还涉及制备式（I）化合物的方法。 本申请进一步描述了式（1）化合物作为胆固醇酯转移蛋白（CETP）抑制剂。 本申请还涉及包含式（1）化合物或其立体异构体或其药学上可接受的盐的药物组合物。
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2.发明公开5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER -TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS 有权5-苄基氨基甲基-6-氨基 - 吡唑并[3,4-b]吡啶衍生物作为胆甾醇酯 - TRANSFER-蛋白（CETP）抑制剂的动脉粥样硬化治疗的
公开(公告)号：EP2760864A1
公开(公告)日：2014-08-06
申请号：EP12816102.3
申请日：2012-09-27
发明人： BORUAH, Anima , ALIKUNJU, Shanavas
IPC分类号： C07D471/04 , A61K31/506 , A61K31/444 , A61K31/437 , A61P9/10
CPC分类号： C07D471/04
摘要： The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R1, R2, Ra, Raa, Rb and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.
摘要翻译： 本申请涉及一系列具有通式（I），包括其立体异构体和/或药学上可接受的盐及其substituiertem吡-zolopyridin -6- cardamines的。 其中R，R1，R2中，Ra，拉加，Rb和n如所定义。 本发明进一步涉及药物组合物，其包含式（I）的化合物。 本申请的化合物是作为CETP抑制剂的用于在患者中降低提高HDL胆固醇和LDL胆固醇是有用的。
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3.发明授权5-BENZYLAMINOMETHYL-6-AMINOPYRAZOLO[3,4-b]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS 有权作为用于治疗动脉粥样硬化的胆甾醇酯转移蛋白（CETP）抑制剂的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物
公开(公告)号：EP2760864B1
公开(公告)日：2018-01-24
申请号：EP12816102.3
申请日：2012-09-27
发明人： BORUAH, Anima , ALIKUNJU, Shanavas
IPC分类号： C07D471/04 , A61K31/506 , A61K31/444 , A61K31/437 , A61P9/10
CPC分类号： C07D471/04
摘要： The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R1, R2, Ra, Raa, Rb and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.
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