公开(公告)号：EP3419646A1

公开(公告)日：2019-01-02

申请号：EP17757011.6

申请日：2017-02-16

申请人： Drexel University

发明人： BLOCK, Timothy, M. ,  WANG, Mengjun ,  MEHTA, Anand

IPC分类号： A61K38/16 ,  C07K16/06 ,  G01N33/68 ,  G01N33/53 ,  G01N33/574

公开(公告)号：EP3056905B1

公开(公告)日：2019-07-24

申请号：EP15186776.9

申请日：2006-05-05

申请人： Philadelphia Health and Education Corporation d/b/a Drexel University College of Medicine

发明人： BLOCK, Timothy ,  MEHTA, Anand ,  COMUNALE, Mary Ann

IPC分类号： G01N33/68 ,  G01N33/574

公开(公告)号：EP4194003A1

公开(公告)日：2023-06-14

申请号：EP22211176.7

申请日：2017-02-16

申请人： Drexel University

发明人： BLOCK, Timothy M. ,  WANG, Mengjun ,  MEHTA, Anand

IPC分类号： A61K38/16 ,  C07K16/06 ,  G01N33/68 ,  G01N33/53 ,  G01N33/574

摘要： Provided are methods, assays, and kits for detecting hepatocellular carcinoma, as well as methods for stratifying subjects among higher and lower risk categories for having hepatocellular carcinoma, and methods of treating and managing treatment of subjects that are suspected or at risk of having hepatocellular carcinoma. Although previous work has attempted to address the need for a highly sensitive, early predictor of hepatocellular carcinoma by assessment of one or more biological factors, none have approached the degree of sensitivity that is required for clinically relevant determination of whether a subject, especially a non-symptomatic subject, has that condition. The present inventors have discovered that certain combinations of factors fulfill this need by conferring a high level of accuracy that was not previously attainable.

公开(公告)号：EP3056905A1

公开(公告)日：2016-08-17

申请号：EP15186776.9

申请日：2006-05-05

申请人： Philadelphia Health and Education Corporation d/b/a Drexel University College of Medicine

发明人： BLOCK, Timothy ,  MEHTA, Anand ,  COMUNALE, Mary Ann

IPC分类号： G01N33/68 ,  G01N33/574

CPC分类号： G01N33/6893 ,  G01N33/57438 ,  G01N2333/4728 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/7028

摘要： Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.

摘要翻译： 公开了用于诊断怀疑患有这种病理学的受试者的肝脏病理学的方法。 所述方法包括定量检测生物流体中的蛋白质上的糖基化，更具体地岩藻糖基化，并将检测到的糖基化与健康或疾病状态中这些蛋白质糖基化的参考值进行比较。