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    CARBOXYMETHYLMANNOGLUCAN AND DERIVATIVE THEREOF
    2.
    发明公开
    CARBOXYMETHYLMANNOGLUCAN AND DERIVATIVE THEREOF 失效
    羧甲基葡聚糖及其衍生物

    公开(公告)号：EP0526649A1

    公开(公告)日：1993-02-10

    申请号：EP92905093.8

    申请日：1992-02-21

    申请人： DRUG DELIVERY SYSTEM INSTITUTE, LTD.

    发明人： INOUE, Kazuhiro 5-6-6, Matsugaoka ,  ITO, Teruomi 6-89-104, Shin-Matsudo ,  KAWAGUCHI, Takayuchi 1-15-2-406, Sugamo ,  AONO, Katsutoshi ,  OKUNO, Satoshi 8-5-18, Waseda ,  YANO, Toshiro 3-1-8-410, Akebono

    IPC分类号： C08B15/00 ,  C08B37/00

    CPC分类号： C08B37/0087 ,  A61K47/61

    摘要： A carboxymethylmannoglucan composed of tetrasaccharide units represented by general formula (I), and a salt thereof; and another carboxymethylmannoglucan wherein part or the whole of the mannopyranose rings of the tetrasaccharide units are opened and part or the whole of those glucopyranose rings, among the glucopyranose rings of the main chain, from which no mannopyranose rings branch off are opened, and a salt thereof: wherein R 1 to R 12 represent each hydrogen or carboxymethyl. These compounds serve as a pharmaceutical carrier useful for retarding the disappearance of a pharmaceutical in blood and enhancing its directivity toward cancer tissues.

    摘要翻译： 由通式（I）表示的四糖单元构成的羧甲基葡甘露糖及其盐; 和另一个羧甲基葡甘露聚糖，其中四糖单元的甘露吡喃糖环的一部分或全部是开放的，并且在主链的吡喃葡萄糖环中未开出甘露吡喃糖环的那些吡喃葡萄糖环的一部分或全部被打开， 其中：R1至R12分别表示氢或羧甲基。 这些化合物可用作药物载体，用于延缓血液中药物的消失并增强其对癌症组织的指向性。