公开(公告)号：EP0569634A1

公开(公告)日：1993-11-18

申请号：EP92304364.0

申请日：1992-05-14

申请人： Drug Delivery Systems Inc.

发明人： Sibalis , Dan

IPC分类号： A61N1/30

CPC分类号： A61N1/0432 ,  A61N1/325

摘要： A transdermal applicator for attachment to the skin having at least one drug reservoir containing at least one drug, and having an electrical connection formed at a surface interface between said reservoir upon contact with said skin; means for causing said at least one drug to move through said interface transdermally and for maintaining said transdermal movement for an extended time period. The means for causing and maintaining transdermal movement including a source of varying electrical potential, said source having one terminal electrically connected to said at least one reservoir at a location away from said skin surface interface and an other terminal in circuit with said skin surface at a location away from said reservoir/skin surface interface. The electrical circuit is formed upon application to the skin of the device, and said circuit connecting from said one source terminal through said at least one reservoir, through said reservoir/skin surface interface, within said skin to said skin surface connected in circuit to said other source terminal, wherein the drug is delivered through said skin when electrical current flows in a first direction in the circuit. The varying electrical potential is the resultant combination by at least one of superposition and selection of a plurality of electrical signals, and the electrical source including at least one of means for storing data representative of said resultant and means for generating the plurality of signals, and means for selecting and superposing the signals in selected time relationships for application to the source terminals.

摘要翻译： 一种用于附着到皮肤的透皮施用器，其具有至少一个含有至少一种药物的药物储存器，并且在与所述皮肤接触时在所述储存器之间的表面界面处形成电连接; 用于使所述至少一种药物透皮穿过所述界面并用于在延长的时间段内保持所述经皮运动的装置。 用于造成和保持透皮运动的装置，包括具有变化的电位的源，所述源具有一个端子，其在远离所述皮肤表面界面的位置处电连接到所述至少一个储存器，并且在所述皮肤表面的电路中与所述皮肤表面电路连接 位置远离所述储存器/皮肤表面界面。 所述电路在施加到所述装置的皮肤上时形成，并且所述电路从所述一个源极端子通过所述至少一个储存器将所述皮肤内的所述储存器/皮肤表面界面连接到所述皮肤表面， 其他源端子，其中当电流在电路中沿第一方向流动时，药物通过所述皮肤递送。 变化的电势是通过叠加和选择多个电信号中的至少一个而产生的组合，并且电源包括用于存储表示所述结果的数据和产生多个信号的装置中的至少一个的装置，以及 用于选择和叠加所选择的时间关系中的信号以供应用于源终端的装置。