公开(公告)号：EP1131320A1

公开(公告)日：2001-09-12

申请号：EP99960471.3

申请日：1999-11-18

申请人： Du Pont Pharmaceuticals Company

发明人： WITYAK, John ,  JADHAV, Prabhakar, K.

IPC分类号： C07D413/06 ,  A61K31/42 ,  A61P7/02

CPC分类号： C07D413/06

摘要： This invention relates to novel isoxazolines of formula (I) or a pharmaceutically acceptable salt form thereof. This invention also relates to novel isoxazolines of formula (I) which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

公开(公告)号：EP1054871A2

公开(公告)日：2000-11-29

申请号：EP99914248.2

申请日：1999-03-29

申请人： Du Pont Pharmaceuticals Company

发明人： PITTS, William, J. ,  JADHAV, Prabhakar, K.

IPC分类号： C07D239/48 ,  C07D239/42 ,  A61K31/505

CPC分类号： C07D239/47 ,  C07D239/49 ,  C07D239/95 ,  C07D251/18 ,  C07D403/06 ,  C07D487/04

摘要： This invention relates to novel heterocycles which are useful as antagonists of the αvβ3 integrin, the α2bβ3 integrin, and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.