公开(公告)号：EP2413951A2

公开(公告)日：2012-02-08

申请号：EP10759166.1

申请日：2010-04-05

申请人： Duke University

发明人： ALAM, S., Munir ,  HAYNES, Barton, F. ,  SEKARAN, Moses, D. ,  TOMARAS, Georgia ,  SHEN, Xiaoying

IPC分类号： A61K38/16 ,  A61K38/08 ,  A61P31/18 ,  A61P31/12

CPC分类号： A61K47/48815 ,  A61K9/1272 ,  A61K38/212 ,  A61K39/12 ,  A61K39/21 ,  A61K47/646 ,  A61K47/6911 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  C12N2740/16134 ,  A61K2300/00

摘要： The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.