公开(公告)号：EP4286001A3

公开(公告)日：2024-07-17

申请号：EP23198559.9

申请日：2017-04-25

申请人： Duke University ,  The University of North Carolina at Chapel Hill

发明人： NICHOLAS, Robert A. ,  LIANG, Xiaofei ,  ZHOU, Pei ,  TOONE, Eric J. ,  GOPALASWAMY, Ramesh ,  NAVAS, Frank. III

IPC分类号： C07C259/06 ,  C07C311/06 ,  C07D203/08 ,  C07D203/18 ,  C07D309/04 ,  A61K31/165 ,  A61P31/04

CPC分类号： C07C259/18 ,  C07C311/06 ,  C07C317/44 ,  C07C2601/0220170501 ,  C07C2601/0820170501 ,  C07C2601/1420170501 ,  C07D309/04 ,  C07D309/10 ,  C07D335/02 ,  C07D263/16 ,  C07D203/08 ,  C07D203/18 ,  C07D207/327 ,  C07D277/40 ,  C07D295/155 ,  C07D213/64 ,  C07C259/06 ,  A61P31/04 ,  C07C237/36 ,  C07C317/06 ,  Y02A50/30

摘要： Disclosed are compounds of formulae:

and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

公开(公告)号：EP4286001A2

公开(公告)日：2023-12-06

申请号：EP23198559.9

申请日：2017-04-25

申请人： Duke University ,  The University of North Carolina at Chapel Hill

发明人： NICHOLAS, Robert A. ,  LIANG, Xiaofei ,  ZHOU, Pei ,  TOONE, Eric J. ,  GOPALASWAMY, Ramesh ,  NAVAS, Frank. III

IPC分类号： A61P31/04

摘要： Disclosed are compounds of formulae:

and pharmaceutically acceptable salts thereof, wherein the variables, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

公开(公告)号：EP3448375A1

公开(公告)日：2019-03-06

申请号：EP17790274.9

申请日：2017-04-25

申请人： Duke University ,  The University of North Carolina at Chapel Hill

发明人： NICHOLAS, Robert, A. ,  LIANG, Xiaofei ,  ZHOU, Pei ,  TOONE, Eric, J. ,  GOPALASWAMY, Ramesh ,  NAVAS, Frank. III

IPC分类号： A61K31/165 ,  C07C237/34