公开(公告)号：EP2920144A1

公开(公告)日：2015-09-23

申请号：EP13855132.0

申请日：2013-11-15

申请人： Duquesne University of the Holy Spirit

发明人： CHAKRABARTY, Suravi ,  MONLISH, Darlene ,  FLAHERTY, Patrick ,  CAVANAUGH, Jane E. ,  POTDAR, Sneha

IPC分类号： C07C229/58

CPC分类号： C07C227/10 ,  C07C229/58

摘要： The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or alkyl. Further, said compounds are inhibitors of MEK 1, 2 and 5. Furthermore, the invention includes methods of making said compounds, compositions including said compounds and uses for inhibiting MEK 1, 2 and 5.

摘要翻译： 本发明一般涉及具有结构I的化合物：其中x代表烷基，芳基或苯基 - 芳基，y各自独立地表示氢或卤素，z代表氢或烷基。 此外，所述化合物是MEK 1,2和5的抑制剂。此外，本发明包括制备所述化合物，包含所述化合物的组合物和用于抑制MEK 1,2和5的方法。