公开(公告)号：EP1430047A1

公开(公告)日：2004-06-23

申请号：EP02762620.9

申请日：2002-09-26

申请人： Egis Gyogyszergyar Rt. ,  EGIS GYOGYSZERGYAR

发明人： BARKOCZY, Júzsef ,  SIMIG, Gyula ,  KOTAY NAGY, Péter ,  LEVAY, György ,  GACSALYI, István ,  MARTONNE MARKO, Bernadett ,  SCHMIDT, Eva ,  EGYED, András ,  KOMPAGNE, Hajnalka ,  LEVELEKI, Csilla ,  MIKLOSNE KOVACS, Anikú ,  SZENASI, Gábor ,  WELLMANN, János ,  HARSING, Lászlú, Gábor

IPC分类号： C07D401/12 ,  A61K31/50 ,  A61P25/22 ,  A61P25/28

CPC分类号： C07D401/12 ,  C07D237/22 ,  C07D403/12 ,  C07D405/12

摘要： The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.

公开(公告)号：EP1567159A1

公开(公告)日：2005-08-31

申请号：EP03777020.3

申请日：2003-11-13

申请人： EGIS GYOGYSZERGYAR RT.

发明人： LEVAY, György ,  GACSALYI, István ,  MARKO, Bernadett ,  SCHMIDT,Eva ,  EGYED, András ,  KOMPAGNE, Hajnalka ,  LEVELEKI, Csilla ,  MIKLOSNE KOVACS, Anikó ,  SZENASI, Gábor ,  WELLMANN, János ,  HARSING, László Gábor ,  BARKOCZY, József ,  SIMIG, Gyula ,  KOTAY NAGY, Péter

IPC分类号： A61K31/501 ,  A61P25/28

CPC分类号： A61K31/501

摘要： The compounds of the general Formula I, wherein R1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R2 is hydrogen or lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R3 and Z together with the intermediate atoms form a piperazino ring; Q and W independently from each other stands for -CH= or -N=; and R4, R5 and R6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R4 and R5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.

公开(公告)号：EP1430047B1

公开(公告)日：2005-02-09

申请号：EP02762620.9

申请日：2002-09-26

申请人： Egis Gyogyszergyar Rt. ,  EGIS GYOGYSZERGYAR

发明人： BARKOCZY, Júzsef ,  SIMIG, Gyula ,  KOTAY NAGY, Péter ,  LEVAY, György ,  GACSALYI, István ,  MARTONNE MARKO, Bernadett ,  SCHMIDT, Eva ,  EGYED, András ,  KOMPAGNE, Hajnalka ,  LEVELEKI, Csilla ,  MIKLOSNE KOVACS, Anikú ,  SZENASI, Gábor ,  WELLMANN, János ,  HARSING, Lászlú, Gábor

IPC分类号： C07D401/12 ,  A61K31/50 ,  A61P25/22 ,  A61P25/28

CPC分类号： C07D401/12 ,  C07D237/22 ,  C07D403/12 ,  C07D405/12

摘要： The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.

摘要翻译： 本发明涉及通式（I）的新的取代的烷基氨基哒嗪酮衍生物，其中R 1是氢或具有1-4个碳原子的烷基; X和Y中的一个代表氢或卤素，另一个代表通式 （II）中，R2是氢或具有1-4个碳原子的烷基; n是1,2或3; R3代表氢，具有1-4个碳原子的烷基或芳基 - （C1-4烷基）; Z代表氧 ;或者R3和Z与它们之间的基团一起形成哌嗪环; R4代表氢，卤素，三氟甲基或具有1-4个碳原子的烷氧基）及其药学上可接受的酸加成盐。 本发明化合物可用于治疗抗焦虑症和认知障碍。