专利检索 ap:("ELC MAN LLC") AND inv:"POLLEFLIET CAROLINE FRANÇOISE" 第 1 页

1.

发明公开
ACTIVES FOR STIMULATING DIFFERENTIATION OF KERATINOCYTES TO LIGHTEN HYPERPIGMENTED SKIN 审中-公开

公开(公告)号：EP3200683A4

公开(公告)日：2018-03-21

申请号：EP15846829

申请日：2015-09-25

申请人： ELC MAN LLC

发明人： POLLEFLIET CAROLINE FRANÇOISE , CORSTJENS HUGO A L , DECLERCQ LIEVE , YAROSH DANIEL B

IPC分类号： A61B5/00 , A61K8/34 , A61K8/49 , A61K8/97 , A61K49/00 , A61Q19/02

CPC分类号： A61K8/498 , A61K8/342 , A61K8/347 , A61K8/4973 , A61K8/97 , A61K49/0006 , A61K49/0008 , A61K2800/805 , A61Q19/02

摘要： A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin.