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公开(公告)号:EP0771196B1
公开(公告)日:1999-12-08
申请号:EP95929416.6
申请日:1995-08-07
发明人: ARNOLD, Macklin Brian , BLEISCH, Thomas J. , HELTON, David Reed , KALLMAN, Mary Jeanne , ORNSTEIN, Paul Leslie , SCHOEPP, Darryle Darwin , TIZZANO, Joseph Patrick
CPC分类号: C07D311/80 , C07C62/12 , C07C62/18 , C07C62/22 , C07C62/26 , C07D211/34 , C07D233/76
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公开(公告)号:EP0771196A1
公开(公告)日:1997-05-07
申请号:EP95929416.0
申请日:1995-08-07
发明人: ARNOLD, Macklin Brian , BLEISCH, Thomas J. , HELTON, David Reed , KALLMAN, Mary Jeanne , ORNSTEIN, Paul Leslie , SCHOEPP, Darryle Darwin , TIZZANO, Joseph Patrick
IPC分类号: B60T8 , A61K31 , A61P25 , A61P43 , C07C62 , C07C227 , C07C229 , C07D207 , C07D211 , C07D233 , C07D311 , C07D333 , C07D521 , F16K27 , F16K31
CPC分类号: C07D311/80 , C07C62/12 , C07C62/18 , C07C62/22 , C07C62/26 , C07D211/34 , C07D233/76
摘要: The present invention provides compounds of formula (I) in which R is as defined in the specification, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists of one or more of the actions of L-glutamate at metabotropic excitatory amino acid receptors.
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