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公开(公告)号：EP0950661B1
公开(公告)日：2003-11-12
申请号：EP99302969.3
申请日：1999-04-16
发明人： Bach, Nicholas James , Bastian, Jolie Anne , Beight, Douglas Wade , Kinnick, Michael Dean , Martinelli, Michael John , Mihelich, Edward David , Morin, John Michael Jr. , Sall, Daniel Jon , Sawyer, Jason Scott , Smith, Edward C.R. , Suarez, Tulio , Wang, Qiuping , Wilson, Thomas Michael
IPC分类号： C07D513/04 , C07D471/04 , C07D491/04 , A61K31/40
CPC分类号： C07D471/04 , C07D491/04 , C07D513/04
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公开(公告)号：EP0950661A1
公开(公告)日：1999-10-20
申请号：EP99302969.3
申请日：1999-04-16
发明人： Bach, Nicholas James , Bastian, Jolie Anne , Beight, Douglas Wade , Kinnick, Michael Dean , Martinelli, Michael John , Mihelich, Edward David , Morin, John Michael Jr. , Sall, Daniel Jon , Sawyer, Jason Scott , Smith, Edward C.R. , Suarez, Tulio , Wang, Qiuping , Wilson, Thomas Michael
IPC分类号： C07D513/04 , C07D471/04 , C07D491/04 , A61K31/40
CPC分类号： C07D471/04 , C07D491/04 , C07D513/04
摘要： A class of novel tricyclics is diclosed of the formula (I)
wherein;
A is phenyl or pyridyl wherein the nitrogen is at the 5-, 6-, 7- or 8-position;
one of B or D is nitrogen and the other is carbon;
Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-, 2-, or 3position, or a 6-membered heterocyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-, 2- or 3-position, and nitrogen at the 1-, 2-, 3- or 4-position;
---- is a double or single bond;
together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.摘要翻译： 一类新颖的三环类的被diclosed式（I）
worin的; A为苯基或吡啶基worin氮是在5-，6-，7-或8-位; B或D之一是氮且另一个是碳; Z是环己烯，苯基，吡啶基，worin氮位于1-，2-，或3位置，或具有在1-，2-或选自硫或氧的选定的一个杂原子的6元杂环 3位和氮在1-，2-，3-或4-位; ----是双键或单键; 与使用测试化合物用于抑制脂肪酸sPLA2介导释放处理的条件一起：如脓毒性休克。 -
公开(公告)号：EP1156050B1
公开(公告)日：2004-02-18
申请号：EP01203116.7
申请日：1999-04-16
发明人： Bach, Nicholas James , Bastian, Jolie Anne , Beight, Douglas Wade , Kinnick, Michael Dean , Martinelli, Michael John , Mihelich, Edward David , Morlin, John Michael, Jr. , Sall, Daniel Jon , Sawyer, Jason Scott , Smith, Edward C. R. , Suarez, Tulio , Wang, Quiping , Wilson, Thomas Michael
IPC分类号： C07D513/04 , C07D471/04 , C07D491/04 , A61K31/40
CPC分类号： C07D471/04 , C07D491/04 , C07D513/04
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公开(公告)号：EP1156050A3
公开(公告)日：2001-11-28
申请号：EP01203116.7
申请日：1999-04-16
发明人： Bach, Nicholas James , Bastian, Jolie Anne , Beight, Douglas Wade , Kinnick, Michael Dean , Martinelli, Michael John , Mihelich, Edward David , Morlin, John Michael, Jr. , Sall, Daniel Jon , Sawyer, Jason Scott , Smith, Edward C. R. , Suarez, Tulio , Wang, Quiping , Wilson, Thomas Michael
IPC分类号： C07D513/04 , C07D471/04 , C07D491/04 , A61K31/40
CPC分类号： C07D471/04 , C07D491/04 , C07D513/04
摘要： A class of novel tricyclics is disclosed of the formula (I) wherein; A is phenil or pyridyl wherein the nitrogen is at the 5-, 6-, 7- or 8-position; one of B or D is nitrogen and the other is carbon; Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-, 2-, or 3-position, or a 6-membered heterocyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-, 2-, 3-position, and nitrogen at the 1-, 2-, 3- or 4-position; is a double or single bond; together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 式（I）公开了一类新型三环类化合物，其中： A是其中氮在5-，6-，7-或8-位的苯基或吡啶基; B或D中的一个是氮而另一个是碳; Z是环己烯基，苯基，吡啶基，其中氮在1位，2位或3位，或6元杂环在1位，2位具有一个选自硫或氧的杂原子 - ，3-位和氮在1-，2-，3-或4-位; 是双键或单键; 以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如感染性休克等病症的用途。
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公开(公告)号：EP1156050A2
公开(公告)日：2001-11-21
申请号：EP01203116.7
申请日：1999-04-16
发明人： Bach, Nicholas James , Bastian, Jolie Anne , Beight, Douglas Wade , Kinnick, Michael Dean , Martinelli, Michael John , Mihelich, Edward David , Morlin, John Michael, Jr. , Sall, Daniel Jon , Sawyer, Jason Scott , Smith, Edward C. R. , Suarez, Tulio , Wang, Quiping , Wilson, Thomas Michael
IPC分类号： C07D513/04 , C07D471/04 , C07D491/04 , A61K31/40
CPC分类号： C07D471/04 , C07D491/04 , C07D513/04
摘要： A class of novel tricyclics is disclosed of the formula (I)
wherein;
A is phenil or pyridyl wherein the nitrogen is at the 5-, 6-, 7- or 8-position;
one of B or D is nitrogen and the other is carbon;
Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-, 2-, or 3-position, or a 6-membered heterocyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-, 2-, 3-position, and nitrogen at the 1-, 2-, 3- or 4-position;
is a double or single bond;
together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.摘要翻译： 一类新颖的三环类的光盘是游离缺失的式（I）
worin的; A是phenil或吡啶基worin氮是在5-，6-，7-或8-位; B或D之一是氮且另一个是碳; Z是环己烯基，苯基，吡啶基，worin氮是在1-，2-，或3-位，或具有选自硫或氧中选择的一个杂原子的6元杂环在1-，2- - ，3位和氮在1-，2-，3-或4-位; 为双键或单键; 与使用测试化合物用于抑制脂肪酸sPLA2介导释放处理的条件一起：如脓毒性休克。
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