公开(公告)号：EP2347654A1

公开(公告)日：2011-07-27

申请号：EP11164838.2

申请日：2001-09-17

申请人： Eli Lilly and Company

发明人： Lowe, Lionel Barry ,  Rothwell, James Terence

IPC分类号： A01N45/02

CPC分类号： A01N43/90 ,  A01N43/22 ,  A01N2300/00

摘要： The present invention relates to an active composition for controlling or eradicating Phthiraptera, Siphonaptera and Acarina Pests, typically in domestic animals, comprising a synergistic combination of at least one A83543 compound and at least one macrocyclic lactone. The invention also relates to the use of the active composition in pesticidal formulations, the formulations themselves and to the various applications of those formulations as pesticides, specifically in controlling all species of Phthiraptera, Siphonaptera and Acarina pests, typically in domestic animals. Such applications include the control of such external Phthiraptera, Siphonaptera and Acarina pests in domestic animals including but not limited to sheep, cattle, poultry, pigs, goats, camelids, horses, dogs and cats.

摘要翻译： 本发明涉及通常在家畜中控制或根除Phthiraptera，Siphonaptera和Acarina Pests的活性组合物，其包含至少一种A83543化合物和至少一种大环内酯的协同组合。 本发明还涉及活性组合物在农药制剂中的用途，制剂本身以及这些制剂作为农药的各种用途，特别是在控制Phthiraptera，Siphonaptera和Acarina害虫的所有物种，通常在家畜中。 这些应用包括对家畜（包括但不限于绵羊，牛，家禽，猪，山羊，骆驼，马，狗和猫）中的这种外部Phthiraptera，Siphonaptera和Acarina害虫的控制。

公开(公告)号：EP0715847A3

公开(公告)日：2003-11-19

申请号：EP96200392.7

申请日：1992-04-03

申请人： ELI LILLY AND COMPANY

发明人： Lowe, Lionel Barry ,  McArthur, Colin John

IPC分类号： A61K9/00 ,  A61M31/00

CPC分类号： A61K9/0068

摘要： A sustained release capsule adapted to be inserted into the rumen of a ruminant animal and means for retention of the capsule in the rumen. A sustained release capsule ( 8 ) adapted to be inserted into the rumen of a ruminant animal through its oesophagus and retained within the rumen over a prolonged period to continuously deliver a biologically active composition ( 32 ) carried in the capsule ( 8 ), comprising an elongated tubular body ( 10 ) comprising a tube ( 16 ) and an end cap ( 12 ) secured to one end thereof for substantially enclosing the biologically active composition ( 32 ), the other end of the capsule ( 8 ) being a delivery end ( 18 ), the body ( 10 ) having an opening ( 20 ) at the delivery end ( 18 ) of the capsule ( 8 ) for delivery of the composition ( 32 ) to the rumen, and a plurality of retention arms ( 44 ) attached to or formed integrally with the cap ( 12 ), the arms ( 44 ) being adapted to extend outwardly from the cap ( 12 ) for retaining the capsule ( 8 ) in the rumen, the arms ( 44 ) being resilient to enable them to bend from their outwardly extending positions toward the body ( 10 ) so that they lie alongside the body ( 10 ) allowing the capsule ( 8 ) to be inserted through the animal's oesophagus, the resilient arms ( 44 ) normally extending from the body ( 10 ) at an angle between 75° and 90° with respect to the axis of the tubular body ( 10 ), and for each arm ( 44 ) said cap ( 12 ) has an external curved surface ( 26 ) disposed with respect to the arm ( 44 ) so that when the arm ( 44 ) is bent toward the body ( 10 ), the arm ( 44 ) contacts the curved surface ( 26 ) and the curved surface ( 26 ) controls the bending of the arm ( 44 ) so that the arm ( 44 ) does not bend abruptly, said arms ( 44 ) being adapted to return to their outwardly extending positions when the capsule ( 8 ) reaches the rumen, characterised in that said cap ( 12 ) is secured to said one end by means of at least two circumferential beads ( 30 ) having at least one sealing ring ( 31 ) located therebetween.

公开(公告)号：EP0671174B1

公开(公告)日：2005-02-02

申请号：EP95301467.7

申请日：1995-03-07

申请人： ELI LILLY AND COMPANY

发明人： Lowe, Lionel Barry

IPC分类号： A61K33/04

CPC分类号： A61K33/04 ,  A61K31/35 ,  A61K2300/00

公开(公告)号：EP0671174A3

公开(公告)日：1999-01-27

申请号：EP95301467.7

申请日：1995-03-07

申请人： ELI LILLY AND COMPANY

发明人： Lowe, Lionel Barry

IPC分类号： A61K33/04

CPC分类号： A61K33/04 ,  A61K31/35 ,  A61K2300/00

摘要： This invention relates to a formulation for increasing weight of livestock comprising an ionophore, selenium and a veterinary acceptable carrier, diluent, excipient and/or adjuvant. The invention also relates to a method of increasing liveweight gain in livestock comprising, administering to said livestock an effective amount of a formulation of the invention. The invention further relates to a method of increasing selenium absorption in livestock comprising, administering to said livestock an effective amount of an ionophore.

公开(公告)号：EP0507629B1

公开(公告)日：1997-01-22

申请号：EP92302997.9

申请日：1992-04-03

申请人： ELI LILLY AND COMPANY

发明人： Lowe, Lionel Barry ,  McArthur, Colin John

IPC分类号： A61K9/00 ,  A23K1/17 ,  A23K1/00

CPC分类号： A61K9/0068

公开(公告)号：EP0715847A2

公开(公告)日：1996-06-12

申请号：EP96200392.7

申请日：1992-04-03

申请人： ELI LILLY AND COMPANY

发明人： Lowe, Lionel Barry ,  McArthur, Colin John

IPC分类号： A61K9/00

CPC分类号： A61K9/0068

摘要： A sustained release capsule adapted to be inserted into the rumen of a ruminant animal and means for retention of the capsule in the rumen.
A sustained release capsule ( 8 ) adapted to be inserted into the rumen of a ruminant animal through its oesophagus and retained within the rumen over a prolonged period to continuously deliver a biologically active composition ( 32 ) carried in the capsule ( 8 ), comprising an elongated tubular body ( 10 ) comprising a tube ( 16 ) and an end cap ( 12 ) secured to one end thereof for substantially enclosing the biologically active composition ( 32 ), the other end of the capsule ( 8 ) being a delivery end ( 18 ), the body ( 10 ) having an opening ( 20 ) at the delivery end ( 18 ) of the capsule ( 8 ) for delivery of the composition ( 32 ) to the rumen, and a plurality of retention arms ( 44 ) attached to or formed integrally with the cap ( 12 ), the arms ( 44 ) being adapted to extend outwardly from the cap ( 12 ) for retaining the capsule ( 8 ) in the rumen, the arms ( 44 ) being resilient to enable them to bend from their outwardly extending positions toward the body ( 10 ) so that they lie alongside the body ( 10 ) allowing the capsule ( 8 ) to be inserted through the animal's oesophagus, the resilient arms ( 44 ) normally extending from the body ( 10 ) at an angle between 75° and 90° with respect to the axis of the tubular body ( 10 ), and for each arm ( 44 ) said cap ( 12 ) has an external curved surface ( 26 ) disposed with respect to the arm ( 44 ) so that when the arm ( 44 ) is bent toward the body ( 10 ), the arm ( 44 ) contacts the curved surface ( 26 ) and the curved surface ( 26 ) controls the bending of the arm ( 44 ) so that the arm ( 44 ) does not bend abruptly, said arms ( 44 ) being adapted to return to their outwardly extending positions when the capsule ( 8 ) reaches the rumen, characterised in that said cap ( 12 ) is secured to said one end by means of at least two circumferential beads ( 30 ) having at least one sealing ring ( 31 ) located therebetween.

摘要翻译： 适于插入反刍动物的瘤胃的持续释放胶囊和将胶囊保留在瘤胃中的装置。 一种缓释胶囊（8），其适于通过其食道插入反刍动物的瘤胃中并在长时间内保留在瘤胃内以连续输送携带在胶囊（8）中的生物活性组合物（32） ），包括细长的管状体（10），其包括管（16）和固定到其一端的端盖（12），用于基本上封闭所述生物活性组合物（32），所述胶囊（8）的另一端为 输送端（18），主体（10）在胶囊（8）的输送端（18）处具有用于将组合物（32）输送到瘤胃的开口（20）和多个保持臂（44） ），所述臂（44）适于从所述盖（12）向外延伸以将所述胶囊（8）保持在所述瘤胃内，所述臂（44）具有弹性，以使它们 从其向外延伸的位置朝向主体（10）弯曲，使得它们与主体（10）一起放置在允许位置 将胶囊（8）插入通过动物的食道，弹性臂（44）通常相对于管状体（10）的轴线以75度和90度之间的角度从主体（10）延伸， 并且对于每个臂（44），所述盖（12）具有相对于臂（44）设置的外部弯曲表面（26），使得当臂（44）朝向主体（10）弯曲时，臂（44） ）接触弯曲表面（26）并且弯曲表面（26）控制臂（44）的弯曲，使得臂（44）不突然弯曲，所述臂（44）适于返回到其向外延伸的位置 当所述胶囊（8）到达所述瘤胃时，其特征在于，所述帽（12）通过至少两个周向珠（30）固定到所述一端，所述周向珠具有位于其间的至少一个密封圈（31）。

公开(公告)号：EP0671174A2

公开(公告)日：1995-09-13

申请号：EP95301467.7

申请日：1995-03-07

申请人： ELI LILLY AND COMPANY

发明人： Lowe, Lionel Barry

IPC分类号： A61K33/04

CPC分类号： A61K33/04 ,  A61K31/35 ,  A61K2300/00

摘要： This invention relates to a formulation for increasing weight of livestock comprising an ionophore, selenium and a veterinary acceptable carrier, diluent, excipient and/or adjuvant. The invention also relates to a method of increasing liveweight gain in livestock comprising, administering to said livestock an effective amount of a formulation of the invention. The invention further relates to a method of increasing selenium absorption in livestock comprising, administering to said livestock an effective amount of an ionophore.

摘要翻译： 本发明涉及一种用于增加家畜重量的制剂，其包括离子载体，硒和兽医学上可接受的载体，稀释剂，赋形剂和/或佐剂。 本发明还涉及一种增加家畜体重增重的方法，包括向所述家畜施用有效量的本发明制剂。 本发明还涉及增加家畜中硒吸收的方法，其包括向所述家畜施用有效量的离子载体。

公开(公告)号：EP0507629A1

公开(公告)日：1992-10-07

申请号：EP92302997.9

申请日：1992-04-03

申请人： ELI LILLY AND COMPANY

发明人： Lowe, Lionel Barry ,  McArthur, Colin John

IPC分类号： A61K9/00 ,  A23K1/17 ,  A23K1/00

CPC分类号： A61K9/0068

摘要： A sustained release capsule ( 8 ) adapted to be inserted into the rumen of a ruminant animal through its oesophagus and retained within the rumen over a prolonged period to continuously deliver a biologically active composition ( 32 ) carried in the capsule ( 8 ), comprising an elongated tubular body ( 10 ) comprising a tube ( 16 ) and an end cap ( 12 ) secured to one end thereof for substantially enclosing the biologically active composition ( 32 ), the other end of the capsule ( 8 ) being a delivery end ( 18 ), the body ( 10 ) having an opening ( 20 ) at the delivery end ( 18 ) of the capsule ( 8 ) for delivery of the composition ( 32 ) to the rumen, and a plurality of retention arms ( 44 ) attached to or formed integrally with the cap ( 12 ), the arms ( 44 ) being adapted to extend outwardly from the cap ( 12 ) for retaining the capsule ( 8 ) in the rumen, the arms ( 44 ) being resilient to enable them to bend from their outwardly extending positions toward the body ( 10 ) so that they lie alongside the body ( 10 ) allowing the capsule ( 8 ) to be inserted through the animal's oesophagus, the resilient arms ( 44 ) normally extending from the body ( 10 ) at an angle between 75° and 90° with respect to the axis of the tubular body ( 10 ), and for each arm ( 44 ) said cap ( 12 ) has an external curved surface ( 26 ) disposed with respect to the arm ( 44 ) so that when the arm ( 44 ) is bent toward the body ( 10 ), the arm ( 44 ) contacts the curved surface ( 26 ) and the curved surface ( 26 ) controls the bending of the arm ( 44 ) so that the arm ( 44 ) does not bend abruptly, said arms ( 44 ) being adapted to return to their outwardly extending positions when the capsule ( 8 ) reaches the rumen, characterised in that said cap ( 12 ) is secured to said one end by means of at least two circumferential beads ( 30 ) having at least one sealing ring ( 31 ) located therebetween.

摘要翻译： 一种缓释胶囊（8），其适于通过其食道插入反刍动物的瘤胃中并在长时间内保留在瘤胃内以连续输送携带在胶囊（8）中的生物活性组合物（32），其包含 细长管状体（10）包括一个固定在其一端上的管子（16）和端盖（12），用于基本上封闭生物活性组合物（32），胶囊（8）的另一端是一个输送端 ），所述主体（10）在胶囊（8）的输送端（18）处具有用于将组合物（32）输送到瘤胃的输送端（18）的开口（20），以及多个保持臂（44） 与盖（12）一体地形成，臂（44）适于从盖（12）向外延伸，以将胶囊（8）保持在瘤胃中，臂（44）具有弹性，使得它们能够从其 朝向身体（10）向外延伸的位置使得它们与身体（10）一起位于允许t 通过动物食管插入的胶囊（8），弹性臂（44）通常相对于管状体（10）的轴线以75°和90°之间的角度从主体（10）延伸，以及 对于每个臂（44），所述盖（12）具有相对于臂（44）设置的外部弯曲表面（26），使得当臂（44）朝向主体（10）弯曲时，臂（44） 接触弯曲表面（26）并且弯曲表面（26）控制臂（44）的弯曲，使得臂（44）不突然弯曲，所述臂（44）适于返回到其向外延伸的位置，当 所述胶囊（8）到达所述瘤胃，其特征在于，所述帽（12）通过至少两个具有位于其间的至少一个密封圈（31）的周向胎圈（30）固定到所述一端。